0000000000141364

AUTHOR

Mariola Iliszko

0000-0001-8439-5713

showing 1 related works from this author

Expression of Female Sex Hormone Receptors, Connective Tissue Growth Factor and HER2 in Gallbladder Cancer

2019

AbstractGallbladder cancer (GBC) is a highly malignant tumor with poorly understood etiology. An insight into phenotypic features of this malignancy may add to the knowledge of its carcinogenesis and pave the way to new therapeutic approaches. We assessed the expression of female sex hormone receptors (ERα, ERβ, PR), connective tissue growth factor (CTGF) and HER2 in GBC, and adjacent normal tissue (NT), and determined their prognostic impact. Immunohistochemical (IHC) expression of all biomarkers was performed in formalin-fixed, paraffin-embedded specimens in 60 Caucasian GBC patients (51 women and 9 men). ERβ, cytoPR and CTGF expression were found in 89%, 27%, 91% of GBC, and in 63%, 87%,…

AdultMale0301 basic medicineReceptor ErbB-2Connective tissuelcsh:MedicinePathogenesismedicine.disease_causeArticleTumour biomarkersGastrointestinal cancer03 medical and health sciencesMedical research0302 clinical medicineBiomarkers TumorHumansMedicineGallbladder cancerReceptorlcsh:ScienceAgedAged 80 and overMultidisciplinarybusiness.industryGallbladderlcsh:RConnective Tissue Growth FactorGastroenterologyGallbladderMiddle AgedPrognosismedicine.diseaseCTGF030104 developmental biologymedicine.anatomical_structureOncologyRisk factorsHormone receptor030220 oncology & carcinogenesisCancer researchImmunohistochemistryFemaleGallbladder Neoplasmslcsh:QbusinessCarcinogenesisBiomarkersScientific Reports
researchProduct