0000000000142310
AUTHOR
Antonio Escobar
Biological and prognostic differences between symptomatic colorectal carcinomas and those detected by screening
REDISSEC-CARESS/CCR group.
Clinical-pathological characteristics and short-term follow-up associated with proliferation, apoptosis and angiogenesis in a prospective cohort of patients with colorectal tumours.
We investigate the clinical and pathological features related to variations in colorectal tumour apoptosis, proliferation and angiogenesis and the influence of the latter in short-term mortality (2 years); 551 tumour samples from a prospective cohort of patients with colorectal cancer were examined and tumour biology markers were determined as follows: percentage of apoptotic cells, by the terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling technique; Ki-67 antigen, as a cell proliferation marker and density of microvessels (as a marker of angiogenesis). An increase in the percentage of cellular apoptosis is significantly related to the presence of poorly differentiated tumo…
Additional file 1: Table S1. of Colorectal cancer health services research study protocol: the CCR-CARESS observational prospective cohort project
Grouping of complications. Table S2. Chemotherapy information at the beginning of the study. (DOCX 17 kb)
Factors that influence treatment delay in patients with colorectal cancer
// Irene Zarcos-Pedrinaci 1, 11 , Alberto Fernandez-Lopez 2 , Teresa Tellez 1, 11 , Francisco Rivas-Ruiz 1, 11 , Antonio Rueda A 3, 11 , Maria Manuela Morales Suarez-Varela 4 , Eduardo Briones 5 , Marisa Bare 6, 11 , Antonio Escobar 7, 11 , Cristina Sarasqueta 8, 11 , Nerea Fernandez de Larrea 9, 11 , Urko Aguirre 10, 11 , Jose Maria Quintana 10, 11 , Maximino Redondo 1, 11 and On Behalf of the CARESS-CCR Study Group 1 Research Unit, Agencia Sanitaria Costa del Sol, Marbella, Spain 2 Servicio de Cirugia, Agencia Sanitaria Costa del Sol, Marbella, Spain 3 Servicio de Oncologia Medica, Agencia Sanitaria Costa del Sol, Marbella, Spain 4 Unit of Public Health, Hygiene and Environmental Health, …
Factors Associated with Prolonged Patient-Attributable Delay in the Diagnosis of Colorectal Cancer
Purpose The delayed diagnosis of colorectal cancer (CRC) may be attributable to sociodemographic characteristics, to aspects of tumour histopathology or to the functioning of the health system. We seek to determine which of these factors most influences prolonged patient-attributable delay (PPAD) in the diagnosis and treatment of CRC. Materials and methods A prospective, multicentre observational study was conducted in 22 Spanish hospitals. In total, 1,785 patients were recruited to the study between 2010 and 2012 and underwent elective or urgent surgery. PPAD is considered to occur when the time elapsed between a patient presenting the symptom and him/her seeking attention from the primary…