0000000000142603

AUTHOR

Pablo Mir

showing 3 related works from this author

Cerebellar magnetic stimulation decreases levodopa-induced dyskinesias in Parkinson disease

2009

BACKGROUND: The neural mechanisms and the circuitry involved in levodopa-induced dyskinesia (LID) are still partially obscure. LID can be considered the consequence of an abnormal pattern or code of activity that originates and is conveyed from the basal ganglia to the thalamus and the cortical motor areas. However, not only striatothalamocortical motor circuits but also other interconnected pathways could be implicated in its pathogenesis. METHODS: In a series of experiments, we applied repetitive transcranial magnetic stimulation (rTMS) over the lateral cerebellum in a group of patients with advanced Parkinson disease, to investigate whether modulation of cerebellothalamocortical circuits…

Dyskinesia Drug-InducedLevodopaCerebellummedicine.medical_treatmentCTBStmSeverity of Illness IndexrehabilitationNOLevodopaNeural PathwaySeverity of Illness Index; Analysis of Variance; Levodopa; Dyskinesia Drug-Induced; Humans; Cerebellum; Aged; Neural Inhibition; Thalamus; Motor Cortex; Parkinson Disease; Evoked Potentials Motor; Neural Pathways; Middle Aged; Neuronal Plasticity; Transcranial Magnetic StimulationThalamusCerebellumNeural PathwaysBasal gangliamedicineHumansEvoked PotentialsThalamuAgedAnalysis of VarianceNeuronal PlasticityDyskinesiaMotor CortexNeural InhibitionParkinson DiseaseMiddle AgedEvoked Potentials MotorTranscranial Magnetic StimulationAged; Analysis of Variance; Cerebellum; Drug-Induced Dyskinesia; Evoked Potentials; Motor; Humans; Levodopa; Middle Aged; Motor Cortex; Neural Inhibition; Neural Pathways; Neuronal Plasticity; Parkinson Disease; Severity of Illness Index; Thalamus; Transcranial Magnetic StimulationTranscranial magnetic stimulationmedicine.anatomical_structureMotorDyskinesiaDrug-Inducedparkinson's diseaseSettore MED/26 - NeurologiaDrug-Induced DyskinesiaNeurology (clinical)Primary motor cortexmedicine.symptomPsychologyNeuroscienceHumanMotor cortexmedicine.drugNeurology
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Changes in intracortical circuits of the human motor cortex following theta burst stimulation of the lateral cerebellum

2008

Objective: The cerebellum takes part in several motor functions through its influence on the motor cortex (M1). Here, we applied the theta burst stimulation (TBS) protocol, a novel form of repetitive Transcranial Magnetic Stimulation (rTMS) over the lateral cerebellum. The aim of this study was to test whether TBS of the lateral cerebellum could be able to modulate the excitability of the contralateral M1 in healthy subjects. Methods: Motor-evoked potentials (MEPs) amplitude, short intracortical inhibition (SICI), long intracortical inhibition (LICI) and short intracortical facilitation (SICF) were tested in the M1 before and after cerebellar continuous TBS (cTBS) or intermittent TBS (iTBS)…

MaleCerebellumTime FactorsTranscranial magnetic stimulation; Cerebellum; Intracortical inhibition; Connectivity; Theta burst stimulation; TMSmedicine.medical_treatmentCTBSFunctional LateralityIntracortical inhibitionCONNECTIVITYNeck MusclesTheta burst stimulationCerebellumTheta RhythmEvoked PotentialsYoung Adult; Theta Rhythm; Analysis of Variance; Neck Muscles; Differential Threshold; Humans; Cerebellum; Electromyography; Hand; Neural Inhibition; Electric Stimulation; Motor Cortex; Evoked Potentials Motor; Adult; Psychomotor Performance; Transcranial Magnetic Stimulation; Time Factors; Female; Functional Laterality; MaleMotor CortexTranscranial Magnetic StimulationSensory SystemsNeck Musclemedicine.anatomical_structureNeurologyMotorCerebellar cortexFemaleSettore MED/26 - NeurologiaPrimary motor cortexPsychologyHumanMotor cortexAdultTime FactorFRONTAL CORTEXDifferential ThresholdSensory systemNOYoung AdultPARIETAL CORTEXPhysiology (medical)medicineHumansAnalysis of VarianceSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaElectromyographyNeural InhibitionEvoked Potentials MotorHandElectric StimulationTranscranial magnetic stimulationElectrophysiologyCerebellum; Connectivity; Intracortical inhibition; Theta burst stimulation; TMS; Transcranial magnetic stimulation;TMSNeurology (clinical)NeurosciencePsychomotor Performance
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Directional Deep Brain Stimulation for Parkinson's Disease: Results of an International Crossover Study With Randomized, Double-Blind Primary Endpoin…

2022

Objective Published reports on directional deep brain stimulation (DBS) have been limited to small, single-center investigations. Therapeutic window (TW) is used to describe the range of stimulation amplitudes achieving symptom relief without side effects. This crossover study performed a randomized double-blind assessment of TW for directional and omnidirectional DBS in a large cohort of patients implanted with a DBS system in the subthalamic nucleus for Parkinson's disease. Materials and methods Participants received omnidirectional stimulation for the first three months after initial study programming, followed by directional DBS for the following three months. The primary endpoint was a…

MaleDeep brain stimulationParkinson's diseasemedicine.medical_treatmentParkinson's diseaseDeep Brain StimulationStimulation03 medical and health sciences0302 clinical medicinemedicineClinical endpointHumanstherapeutic windowNeurostimulationTherapeutic windowCross-Over Studiesbusiness.industrydirectional programmingParkinson DiseaseGeneral Medicinemedicine.diseaseCrossover studySubthalamic nucleusAnesthesiology and Pain MedicineTreatment OutcomeNeurologyAnesthesiaQuality of LifeFemaleNeurology (clinical)business030217 neurology & neurosurgery
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