0000000000143049
AUTHOR
Jan Ejderhamn
Previous antibacterial treatment due to concomitant infections in preschool children is associated with a lower Helicobacter pylori positivity
Use of antimicrobial agents has been proposed as 1 of the factors that contribute to the loss of Helicobacter pylori (H. pylori) infection. The aim of the study was to investigate the influence of a previous treatment with antibiotics on the prevalence of H. pylori infection in preschool children. Parents of 146 asymptomatic children (aged 0.5-5 y; no antibiotic treatment during the previous 4 weeks) completed a questionnaire about previous treatment with antibiotics and socioeconomic status. Infection with H. pylori was assessed by the monoclonal stool antigen test. H. pylori positivity was 18% (27/146). It was significantly lower in children who had been treated with antibiotics previousl…
Helicobacter pyloriinfection among children with gastrointestinal symptoms: a high prevalence of infection among patients with reflux oesophagitis
Aim: To investigate the link between H.pylori infection and dyspepsia in children, and association with reflux oesophagitis. Patients and Methods: H.pylori status was detected by rapid urease test and/or culture in 130 consecutive symptomatic children coming for upper gastrointestinal endoscopy: 40 – aged 8–12 years (55% boys); 90 – aged 13–18 years (21% boys). Endoscopic findings were analyzed. H.pylori prevalence in the age group 8–12 years was compared to the prevalence among 55 asymptomatic children, aged 7–12 years (13C–urea breath test). Statistical analysis: χ2 test, Fisher's test, and logistic regression analysis. Results: The prevalence of H.pylori infection among patients with gas…
Infection with cagA -Positive and cagA -Negative Types of Helicobacter pylori Among Children and Adolescents with Gastrointestinal Symptoms in Latvia
In order to determine the prevalence of concomitant cagA-positive and cagA-negative Helicobacter pylori genotypes in individual subjects, a group of 56 symptomatic patients (aged 8-18 years) was studied. Among 31 patients culture-positive for Helicobacter pylori, only cagA-positive colonies were isolated from 18 patients, both cagA-positive and cagA-negative genotypes were isolated from 4 patients, and in 9 patients all of the individual colonies isolated were cagA-negative, but in seven of them a pool of colonies was positive for cagA. Thus, the presence of both cagA-positive and cagA-negative genotypes in the same individual was identified in 11 of the 31 culture-positive patients tested,…