0000000000145620
AUTHOR
Esposito E
A rapid and quantitative technique to study striatal dopaminergic neurodegeneration by in vivo reverse microdialysis in rats
Selective stimulation of serotonin2c receptors blocks the enhancement of striatal accumbal dopamine release by nicotine administration
Unilateral Nigral Lesion Induces Dramatic Bilateral Modification In Rat Brain Monoamine Levels: A Neurochemical Study.
ROLE OF CENTRAL 5-HT2C RECEPTOR IN THE CONTROLL OF BASAL GANGLIA FUNCTIONS
MUSCARINIC MODULATION OF THE ACTIVITY OF THE SUBSTANTIA NIGRA PARS COMPACTA NEURONS IN RATS: ROLE OF THE TEGMENTAL PEDUNCULOPONTINE NUCLEUS
7-Nitroindazole protects striatal neurons against MPP+ -induced degeneration.
The neuropathological hallmark of Parkinson's disease (PD) is the selective degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNc). In this study, using a microdialysis technique, we investigated whether an inhibitor of neuronal nitric oxide synthase (nNOS), 7-nitrindazole (7-NI), could protect against DAergic neuronal damage induced by in vivo infusion of 1-methyl-4-phenylpiridinium iodide (MPP+) in freely moving rats. Experiments were performed over 2 days in three groups of rats: (a) nonlesioned, (b) MPP+-lesioned, and (c) 7-NI pretreated MPP+-lesioned rats. On day 1, control rats were perfused with an artificial CSF, while 1 mM MPP+ was infused into t…
Involvement of nitric oxide in the nigrostriatal dopaminergic system degeneration: a study on the 6-OHDA model of Parkinson's disease.
INFLAMMATION IN PARKINSON'S DISEASE
The Life Cycle of the Dopaminergic Neurons in the Substantia Nigra
Inflammation in Parkinson's Disease: Therapeutic Implications.
ROLE OF CENTRAL 5-HT2C RECEPTOR IN THE CONTROLL OF BASAL GANGLIA FUNCTIONS.
The Pivotal Role of Nitric Oxide in 6-OHDA-induced Dopaminergic Neurotoxicity: Neurochemical Evidences in Rats
Serotonin modulation of the basal ganglia circuitry : therapeutic implication for Parkinson’s disease and other motor disorders
Several recent studies have emphasized a crucial role for the interactions between serotonergic and dopaminergic systems in movement control and the pathophysiology of basal ganglia. These observations are supported by anatomical evidence demonstrating large serotonergic innervation of all the basal ganglia nuclei. In fact, serotonergic terminals have been reported to make synaptic contacts with both substantia nigra dopamine-containing neurons and their terminal areas such as the striatum, the globus pallidus and the subthalamus. These brain areas contain a high concentration of serotonin (5-HT), with the substantia nigra pars reticulata receiving the greatest input. In this chapter, the d…
Serotonin-Dopamine Interaction: Experimental and Therapeutic Evidence
This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and behavioral data of the serotonin (5-HT)-dopamine (DA) interactions. Central serotonergic and dopaminergic systems play a critical role in the regulation of normal and abnormal behaviors. Moreover, recent evidence suggests that the dysfunction of the DA and 5-HT neurotransmitter systems contribute to various mental disorders including depression, schizophrenia, drug addiction and Parkinson’s disease. This extremely important topic is of wide interest within the scientific community, with relevance not only to specialists but also to general practitioners an…