New insight in primary and secondary osteoporosis: potential new genetic and biochemical marker

Analysis of genetic markers for the optimization of an individualized approach to osteoporosis.

Aim of this study: Osteoporosis is a systemic skeletal disease characterized by compromised bone structure and resistance and by an increased risk of fracture especially in postmenopausal women. Multiple factors including hormonal, environmental and genetic factors are involved in osteoporosis development and clinical outcome. It has been shown that Klotho and insulin-like growth factor-1 (IGF-1) have a significant effect on aging and osteoporosis risk. Actually, Insulin-like growth factor-1 (IGF-1) is a critical polypeptide that plays an important role in the regulation of bone metabolism, which promotes bone cell growth, differentiation, cell cycle progression. Klotho modulates aging in m…

Analysis of Klotho 1 gene variants in not melanocytic skin cancer

Aim of the study: The incidence of the vast majority of cancers, including melanoma and not melanocytic skin cancer (NMSC) increases with advancing age. However, the mechanism by which aging influences the risk of developing cancer is not fully understood. Whether this is attributable to declines in immunity or other changes, such as changes in the aging microenvironment, remains unclear. Amongst the many proteins implicated in aging is the protein Klotho. Loss of Klotho function results in the early appearance of several pathologies associated with human aging, downregulation of Klotho was found in several cancers, such as pancreatic cancer, HCC, and other tumors. Downregulation of Klotho …