0000000000147101
AUTHOR
Andrey Ivanov
Search for muoproduction of X(3872) at COMPASS and indication of a new state X˜(3872)
Abstract We have searched for exclusive production of exotic charmonia in the reaction μ + N → μ + ( J / ψ π + π − ) π ± N ′ using COMPASS data collected with incoming muons of 160 GeV/c and 200 GeV/c momentum. In the J / ψ π + π − mass distribution we observe a signal with a statistical significance of 4.1 σ. Its mass and width are consistent with those of the X ( 3872 ) . The shape of the π + π − mass distribution from the observed decay into J / ψ π + π − shows disagreement with previous observations for X ( 3872 ) . The observed signal may be interpreted as a possible evidence of a new charmonium state. It could be associated with a neutral partner of X ( 3872 ) with C = − 1 predicted b…
Toluidine Blue Test for Sperm DNA Integrity and Elaboration of Image Cytometry Algorithm
Background: Sperm DNA integrity is of paramount importance in the prognosis of fertility. We applied image cytometry to a toluidine blue (TB) test we recently proposed. Methods: Sperm samples from 33 men were assayed for standard sperm parameters and classified as normal or abnormal. Sperm smears were subjected to the TB test, DNA denaturation testing with acridine orange (AO), and terminal deoxyuridine triphosphate biotin nick end labeling (TUNEL). In CCD image analysis, TB-stained sperm cell heads were microscopically assigned to one of four color groups (dark, blue, light violet, and light blue). The optical densities of 6,600 cells in green and red CCD images were used to elaborate an a…
DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells.
Recent studies have highlighted an apparently paradoxical link between self-renewal and senescence triggered by DNA damage in certain cell types. In addition, the finding that TP53 can suppress senescence has caused a re-evaluation of its functional role in regulating these outcomes. To investigate these phenomena and their relationship to pluripotency and senescence, we examined the response of the TP53-competent embryonal carcinoma (EC) cell line PA-1 to etoposide-induced DNA damage. Nuclear POU5F1/OCT4A and P21CIP1 were upregulated in the same cells following etoposide-induced G 2M arrest. However, while accumulating in the karyosol, the amount of OCT4A was reduced in the chromatin fract…