0000000000147498
AUTHOR
W Schönberger
showing 5 related works from this author
SEXUALHORMONE-BINDING GLOBULINE (SHBG) AND FREE TESTOSTERONE (FTE) IN PATIENTS WITH ULLRICH TURNLR SYNDROME(UTS) RECEIVING OXANDROLONE
1993
Our investigation showed that the concentration of SHBG decreased in healthy girls and boys at increased FIE concentrations. It was therefore the aim of the present study to examine the effects of anabolic steroid oxandrolone in SHBG and FTE concentrations in patients with Turner's syndrome. The normal dose to promote growth in patients wilh UTS is 0,1 mg/kg/BW. Our patients received a very low dose of 1,25 mg oxandrolone/doy. We analysed 21 sera of UTS patients. The determination of SHBG concentrations was performed with the IRMA (Famos diagnostics, Oulunsala, Finnland), the concentration of FTE was determined with the RIA (Immunchem.Corporation, Carson, USA). In 7 untreated UIS patients w…
Radioimmunological determination of somatomedin B in healthy children and patients with HGH deficiency
1979
In 192 boys and girls, aging from 1 month to 16 years, serum somatomedin B levels were performed by radioimmunoassay of Kabi Inc., slightly modified. In girls the mean value increased from the 1 st. month at the end of the second year of live from 10.5±6.2 to 19.2±9.2 mg/1, in boys at the same time from 10±3.9 to 20.3±6.2 mg/1. The values decreased in girls in the following years up to the age of 14-16 years to 13.7±7.5 mg/1; in the boys to 11.5±4.2mg/1. The beginning of the decrease was in girls two years earlier than in boys. To these values of normal children were compared the values of 8 patients with HGH deficiency. The mean of these cildren was 4.2 mg/1, significantly below the values…
Behandlung der ausgeprägten Pubertätsgynäkomastie mit Tamoxifen
1987
Based on the good results of another author 10 boys with marked pubertal gynecomastia were treated with the antioestrogen Tamoxifen (Nolvadex) at a dose of 20-40 mg/d orally for 2-12 months. In most cases the gynecomastia decreased totally, only two patients experienced palpable subareolar glandular tissue at the end of therapy. Side effects were not noted. During therapy levels of estradiol and testosteron increased, with a more pronounced elevation of estradiol. Basal values of LH and FSH remained nearly unchanged, but LH showed an increased response to LH-RH, which could be explained by the antioestrogenic effect of Tamoxifen at the hypothalamic level. The reduction of breast size in spi…
MR IMAGING AND HORMONAL FINDINGS IN PATIENTS WITH IDIOPATHIC GROWTH HORMONU DEFICIENCY
1993
Until the introduction of MR imaging in neuroradiological diagnostic, diagnosis of the ecotopic posterior pituitary lobe, first described by the pathologist Priesel in 1920, was rare. Recently it has increasingly been diagnosed by MR in patients whose anamnesis showed birth trauma. We performed MR of the hypothalamic-pituitary region in 17 patients with idiopathic growth hormone deficiency. 8 patients had additional deficiencies of the anterior pituitary lobe whereas the function of the posterior lobe of the hypophysis was normal in all patients. Indications of birth trauma were present in only 2 patients. The cause of anterior lobe insufficiency was determined by MR in 8 patients with panh…
Phenotypic variability in patients with generalised resistance to thyroid hormone.
1995
Genetic linkage of generalised resistance to thyroid hormone (GRTH) to the human thyroid receptor beta 1 gene has been identified. To date 38 different mutations in several kindreds have been documented. We report on a family with GRTH displaying an adenine for guanine substitution at nucleotide 1234 resulting in a threonine for alanine substitution at codon 317 of exon 9. This mutation has been described for different phenotypes, suggesting that the heterogeneity in GRTH may be the result of multiple genetic factors.