6533b7d2fe1ef96bd125e8bb

RESEARCH PRODUCT

Radioimmunological determination of somatomedin B in healthy children and patients with HGH deficiency

Stefan WirthW SchönbergerA. RothW Grimm

subject

medicine.medical_specialtyEndocrinologySomatomedin Bbusiness.industryInternal medicinePediatrics Perinatology and Child HealthNormal childrenMean valuemedicineRadioimmunoassaybusiness

description

In 192 boys and girls, aging from 1 month to 16 years, serum somatomedin B levels were performed by radioimmunoassay of Kabi Inc., slightly modified. In girls the mean value increased from the 1 st. month at the end of the second year of live from 10.5±6.2 to 19.2±9.2 mg/1, in boys at the same time from 10±3.9 to 20.3±6.2 mg/1. The values decreased in girls in the following years up to the age of 14-16 years to 13.7±7.5 mg/1; in the boys to 11.5±4.2mg/1. The beginning of the decrease was in girls two years earlier than in boys. To these values of normal children were compared the values of 8 patients with HGH deficiency. The mean of these cildren was 4.2 mg/1, significantly below the values of the normals. The determination of somatomedin B with the tested radioimmunoassay may be useful for the screening of HGH deficiency in short children.

https://doi.org/10.1203/00006450-197910000-00100