0000000000149552

AUTHOR

Mara Cercignani

showing 3 related works from this author

Structural brain correlates of IQ changes in bipolar disorder

2006

Background. There is increasing evidence that cognitive deficits are present in bipolar disorder (BP), but their neural correlates have not been fully explored. The aim of this study is to correlate structural brain abnormalities with cognitive performance in BP and to explore differences between clinical subtypes. Method. Thirty-six BP patients (13 men, 23 women) with a mean age of 39 years (range 21–63 years) underwent neuropsychological testing and imaging. Twenty-five patients had bipolar disorder I (BP I) and 11 had bipolar disorder II (BP II). Patients with co-morbid psychiatric diagnosis, drug and alcohol abuse or systemic illness were excluded. Correlations between cognitive perform…

AdultMalemedicine.medical_specialtyBipolar DisorderIntelligenceNeuropsychological TestsSuperior temporal gyrusGyrusInternal medicinemedicineHumansBipolar disorderEffects of sleep deprivation on cognitive performanceApplied PsychologyDepression (differential diagnoses)Settore M-PSI/02 - Psicobiologia E Psicologia FisiologicaIntelligence quotientBrainMiddle AgedImage Enhancementmedicine.diseaseMagnetic Resonance ImagingUncusPsychiatry and Mental healthmedicine.anatomical_structureMultivariate AnalysisCardiologyRegression AnalysisFemaleIQ bipolar disordermedicine.symptomCognition DisordersPsychologyManiaNeurosciencePsychological Medicine
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"I Know that You Know that I Know": Neural Substrates Associated with Social Cognition Deficits in DM1 Patients.

2016

Myotonic dystrophy type-1 (DM1) is a genetic multi-systemic disorder involving several organs including the brain. Despite the heterogeneity of this condition, some patients with non-congenital DM1 can present with minimal cognitive impairment on formal testing but with severe difficulties in daily-living activities including social interactions. One explanation for this paradoxical mismatch can be found in patients' dysfunctional social cognition, which can be assessed in the framework of the Theory of Mind (ToM). We hypothesize here that specific disease driven abnormalities in DM1 brains may result in ToM impairments. We recruited 20 DM1 patients who underwent the "Reading the Mind in th…

MaleSocial CognitionMagnetic Resonance SpectroscopyTheory of MindAdult; Brain; Cognition; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Myotonic Dystrophy; Neuropsychological Tests; Social Behavior; Theory of MindSocial Scienceslcsh:MedicineDiseaseNeuropsychological TestsDiagnostic RadiologyCognition0302 clinical medicineFunctional Magnetic Resonance ImagingTheory of mindMedicine and Health SciencesPsychologyMyotonic Dystrophylcsh:ScienceCognitive ImpairmentBrain MappingMultidisciplinarymedicine.diagnostic_testCognitive NeurologyRadiology and Imagingagricultural and biological sciences (all); biochemistry genetics and molecular biology (all); medicine (all)05 social sciencesRBrainCognitionMiddle AgedMagnetic Resonance ImagingNeurologyRC0346Genetic DiseasesPhysical SciencesFemaleSettore MED/26 - NeurologiaPsychologyResearch ArticleClinical psychologyAdultmusculoskeletal diseasesComputer and Information Sciencesmedicine.medical_specialtycongenital hereditary and neonatal diseases and abnormalitiesSocial PsychologyImaging TechniquesCognitive NeuroscienceNeuroimagingDysfunctional familyResearch and Analysis MethodsMyotonic dystrophy050105 experimental psychology03 medical and health sciencesDiagnostic MedicineSocial cognitionTheory of mind cerebral lesionGeneticsmedicineHumans0501 psychology and cognitive sciencesSocial BehaviorPsychiatryClinical GeneticsSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicalcsh:RCognitive PsychologyBiology and Life SciencesHuman Geneticsmedicine.diseaseComprehensionGraph TheoryRC0321Cognitive Sciencelcsh:QFunctional magnetic resonance imagingMathematics030217 neurology & neurosurgeryNeurosciencePLoS ONE
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In vivo definition of parieto-motor connections involved in planning of grasping movements

2010

We combined bifocal transcranial magnetic stimulation (TMS) and diffusion tensor imaging (DTI) tractography to investigate in humans the contribution of connections originating from different parietal areas in planning of different reaching to grasp movements. TMS experiments revealed that in the left hemisphere functional connectivity between the primary motor cortex (M1) and a portion of the angular gyrus (AG) close to the caudal intraparietal sulcus was activated during early preparation of reaching and grasping movements only when the movement was made with a whole hand grasp (WHG) towards objects in contralateral space. In contrast, a different pathway, linking M1 with a part of the su…

Malegenetic structuresCognitive Neurosciencemedicine.medical_treatmentIntraparietal sulcusMotor Activitybehavioral disciplines and activitiesFunctional LateralityLateralization of brain functionNOSuperior longitudinal fasciculusAngular gyrusYoung AdultSupramarginal gyrusParietal LobeNeural PathwaysmedicineHumansYoung Adult; Diffusion Tensor Imaging; Humans; Hand; Motor Skills; Parietal Lobe; Frontal Lobe; Motor Cortex; Evoked Potentials Motor; Motor Activity; Neural Pathways; Psychomotor Performance; Transcranial Magnetic Stimulation; Female; Functional Laterality; MaleEvoked PotentialsConnectivitySettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicamusculoskeletal neural and ocular physiologySuperior longitudinal fasciculusMotor CortexEvoked Potentials MotorHandTranscranial Magnetic StimulationFrontal LobeTranscranial magnetic stimulationTMS Connectivity Movement planning Superior longitudinal fasciculusTractography Transcranial magnetic stimulationDiffusion Tensor Imagingmedicine.anatomical_structureConnectivity; Movement planning; Superior longitudinal fasciculus; TMS; Tractography; Transcranial magnetic stimulation;Motornervous systemNeurologyMotor SkillsMovement planningTMSFemaleSettore MED/26 - NeurologiaPrimary motor cortexPsychologyTractographyNeurosciencePsychomotor Performancepsychological phenomena and processesTractographyNeuroImage
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