0000000000149561

AUTHOR

Kristaps Blums

showing 2 related works from this author

The comparison of knee osteoarthritis treatment with single-dose bone marrow-derived mononuclear cells vs. hyaluronic acid injections

2017

Objective: The aim of this study was to compare treatment methods of the knee joint degenerative osteoarthritis, using autologous bone marrow-derived mononuclear cells and hyaluronic acid injections and observe prevalence of adverse effects in both groups. Materials and methods: A prospective randomized controlled clinical trial was carried out. The analysis of pain and changes in osteoarthritis symptoms after a single intra-articular bone marrow-derived mononuclear cell injection into the knee joint in the Kellgren– Lawrence stage II–III osteoarthritis during the 12-month period were performed. The results were compared with the control group treated routinely by hyaluronic acid injections…

Malemusculoskeletal diseasesmedicine.medical_specialtySodium hyaluronateKnee osteoarthritis; Bone marrow mononuclear cells; CartilageUrologyOsteoarthritisKnee JointPeripheral blood mononuclear cellMonocytesInjections Intra-Articular03 medical and health scienceschemistry.chemical_compound0302 clinical medicineStatistical significanceHyaluronic acidHumansMedicineHyaluronic AcidAdverse effectAgedBone Marrow TransplantationMedicine(all)030203 arthritis & rheumatology030222 orthopedicslcsh:R5-920business.industryMiddle AgedOsteoarthritis Kneemedicine.diseaseTreatment Outcomemedicine.anatomical_structureCartilagechemistryAutomotive EngineeringBone marrow mononuclear cellsFemaleBone marrowKnee osteoarthritisbusinesslcsh:Medicine (General)Medicina
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Treatment of Knee Osteoarthritis with Bone Marrow-Derived Mononuclear Cell Injection: 12-Month Follow-up.

2018

Objectives To evaluate the main symptoms of knee osteoarthritis (OA) and tissue structure changes after a single dose bone marrow–derived mononuclear cell (BM MNC) intra articular injection. Case series study. Patients with knee OA Kellgren Lawrence (K-L) grade II and III received 1 injection of BM MNC. The clinical results were analyzed with the Knee injury and Osteoarthritis Outcome Score (KOOS) and Knee Society Score (KSS) before, 3, 6, and 12 months after injection. Radiological evaluation was performed with a calibrated x-ray and the magnetic resonance (MR) imaging before and 6 to 7 months postinjection. Results A total of 34 knees were treated with BM MNC injections. Mean (±SD) age of…

musculoskeletal diseasesAdultMalePathologymedicine.medical_specialtyKnee JointBiomedical EngineeringPhysical Therapy Sports Therapy and RehabilitationArticular cartilageOsteoarthritisPeripheral blood mononuclear cellSeverity of Illness IndexInjections Intra-Articular03 medical and health sciences0302 clinical medicineIntra articularClinical PapersmedicineImmunology and AllergyHumans030203 arthritis & rheumatologybusiness.industryHematopoietic Stem Cell Transplantation030229 sport sciencesMiddle AgedOsteoarthritis Kneemedicine.diseaseMagnetic Resonance ImagingRadiographymedicine.anatomical_structureTreatment OutcomeLeukocytes MononuclearFemaleBone marrowStem cellbusinessMonth follow upFollow-Up StudiesCartilage
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