6533b7d1fe1ef96bd125cd2a

RESEARCH PRODUCT

The comparison of knee osteoarthritis treatment with single-dose bone marrow-derived mononuclear cells vs. hyaluronic acid injections

Kristaps ErglisEriks JakobsonsLiene PatetkoAndrejs ĒRglisIeva BriedeMartins ErglisValdis GoncarsKristaps BlumsIndrikis MuiznieksKonstantins Kalnberzs

subject

Malemusculoskeletal diseasesmedicine.medical_specialtySodium hyaluronateKnee osteoarthritis; Bone marrow mononuclear cells; CartilageUrologyOsteoarthritisKnee JointPeripheral blood mononuclear cellMonocytesInjections Intra-Articular03 medical and health scienceschemistry.chemical_compound0302 clinical medicineStatistical significanceHyaluronic acidHumansMedicineHyaluronic AcidAdverse effectAgedBone Marrow TransplantationMedicine(all)030203 arthritis & rheumatology030222 orthopedicslcsh:R5-920business.industryMiddle AgedOsteoarthritis Kneemedicine.diseaseTreatment Outcomemedicine.anatomical_structureCartilagechemistryAutomotive EngineeringBone marrow mononuclear cellsFemaleBone marrowKnee osteoarthritisbusinesslcsh:Medicine (General)

description

Objective: The aim of this study was to compare treatment methods of the knee joint degenerative osteoarthritis, using autologous bone marrow-derived mononuclear cells and hyaluronic acid injections and observe prevalence of adverse effects in both groups. Materials and methods: A prospective randomized controlled clinical trial was carried out. The analysis of pain and changes in osteoarthritis symptoms after a single intra-articular bone marrow-derived mononuclear cell injection into the knee joint in the Kellgren– Lawrence stage II–III osteoarthritis during the 12-month period were performed. The results were compared with the control group treated routinely by hyaluronic acid injections therapy. A therapy group of patients (n = 28) received single bone marrow-derived mononuclear cell intra-articular injections. A control group of patients (n = 28) was treated with a total of three sodium hyaluronate intra-articular injections each one performed a week apart. The clinical results were obtained using the Knee Osteoarthritis Outcome Score (KOOS) and the Knee Society Score (KSS) before and 3, 6, and 12 months after injection.Results: A statistically significant improvement was observed in the mononuclear cell group over the starting point in all scores. At the endpoint at month 12, the KOOS score improved significantly (P &lt

yearjournalcountryeditionlanguage
2017-03-22Medicina
10.1016/j.medici.2017.02.002http://www.sciencedirect.com/science/article/pii/S1010660X17300150