0000000000153299

AUTHOR

Koen Bolhuis

showing 3 related works from this author

Genetic association study of childhood aggression across raters, instruments, and age

2021

AbstractChildhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data, i.e., within rater, instrument and age. SNP-heritability for the overall meta-analysis (AGGoverall) was 3.31% (SE = 0.0038). We found no genome-wide significant SNPs for AGGoverall. The gene-based analysis returned three sign…

0301 basic medicineDISORDER/45/43Genome-wide association study3124 Neurology and psychiatry0302 clinical medicineChildPsychiatry0303 health sciences:trastornos mentales [PSIQUIATRÍA Y PSICOLOGÍA]HERITABILITYMental DisordersCognitionGenomicsExplained variationJustice and Strong InstitutionsAggressionPsychiatry and Mental healthMeta-analysisADOLESCENCEChild Preschool:conducta y mecanismos de la conducta::conducta::síntomas conductuales::agresión [PSIQUIATRÍA Y PSICOLOGÍA]/631/208/212/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemaleBiological psychiatrymedicine.symptomLife Sciences & Biomedicine:Investigative Techniques::Genetic Techniques::Genetic Association Studies [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]BEHAVIORRC321-571Childhood aggressionClinical psychologySDG 16 - PeaceAdolescent:Mental Disorders [PSYCHIATRY AND PSYCHOLOGY]Neurosciences. Biological psychiatry. NeuropsychiatrySingle-nucleotide polymorphismBiology3121 Internal medicineMalalties mentals - Aspectes genèticsGenetic correlationArticle1117 Public Health and Health ServicesCellular and Molecular Neuroscience03 medical and health sciences/631/477/2811SDG 3 - Good Health and Well-beingHuman behaviourmedicineSNPHumansGENOME-WIDE ASSOCIATIONBiological PsychiatryGenetic Association Studies030304 developmental biologyGenetic associationRetrospective Studies:técnicas de investigación::técnicas genéticas::estudios de asociación genética [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]Science & TechnologyAggressionSDG 16 - Peace Justice and Strong InstitutionsInfant:Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Aggression [PSYCHIATRY AND PSYCHOLOGY]1103 Clinical SciencesAgressivitat en els infantsHeritability/dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions030104 developmental biology1701 PsychologyORIGINSResearch Programm of Donders Centre for Neuroscience3111 BiomedicineTRAJECTORIES030217 neurology & neurosurgeryDemographyGenome-Wide Association Study
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Childhood aggression and the co-occurrence of behavioural and emotional problems: results across ages 3–16 years from multiple raters in six cohorts …

2018

Childhood aggression and its resulting consequences inflict a huge burden on affected children, their relatives, teachers, peers and society as a whole. Aggression during childhood rarely occurs in isolation and is correlated with other symptoms of childhood psychopathology. In this paper, we aim to describe and improve the understanding of the co-occurrence of aggression with other forms of childhood psychopathology. We focus on the co-occurrence of aggression and other childhood behavioural and emotional problems, including other externalising problems, attention problems and anxiety-depression. The data were brought together within the EU-ACTION (Aggression in Children: unravelling gene-…

MaleNetherlands Twin Register (NTR)aggressiivisuusPoison controlCHILDRENCBCLComorbidity3124 Neurology and psychiatryCohort Studies0302 clinical medicine3123 Gynaecology and paediatricsADOLESCENTSCo-occurrenceDevelopmental and Educational PsychologyChild and adolescent psychiatryChild10. No inequalitykomorbiditeettiOUTCOMESATTENTION-DEFICIT/HYPERACTIVITY DISORDERHERITABILITY05 social sciencesBIPOLAR DISORDERGeneral MedicineStrengths and Difficulties Questionnairetunne-elämän häiriötJustice and Strong InstitutionsAggressionPsychiatry and Mental healthConduct disorderDUTCH TWINSChild PreschoolFemalemedicine.symptomPsychology050104 developmental & child psychologyClinical psychologyCHARACTERISTIC CURVE ANALYSISmedicine.medical_specialtySDG 16 - PeaceAdolescent515 PsychologyChild psychopathologyChild Behavior Disorders03 medical and health sciencesMENTAL-DISORDERSInjury prevention/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_medicineHumans0501 psychology and cognitive sciencesAffective SymptomsBehavioural and emotional problemsAggressionSDG 16 - Peace Justice and Strong Institutionslapsuusmedicine.disease/dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutionsChildhoodkäyttäytymishäiriötCONDUCT DISORDERPediatrics Perinatology and Child HealthCo-occurence030217 neurology & neurosurgery
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Teacher-rated aggression and co-occurring behaviors and problems among schoolchildren: A comparison of four population-based European cohorts

2019

AbstractAggressive behavior in school is an ongoing concern, with the current focus mostly on specific manifestations such as bullying and extreme violence. Children spend a substantial amount of time in school, but their behaviors in the school setting tend to be less well characterized than in the home setting. Since aggression may index multiple behavioral problems, we assessed associations of teacher-rated aggressive behavior with co-occurring externalizing/internalizing problems and social behavior in 39,936 schoolchildren from 4 population-based cohorts from Finland, the Netherlands, and the UK. Mean levels of aggressive behavior differed significantly by gender. Correlations of aggre…

050103 clinical psychologyAggressioneducation05 social sciencesSchool settingNegative associationPopulation based16. Peace & justiceHome settingDevelopmental psychologyProsocial behaviorCo occurringCohortmedicine0501 psychology and cognitive sciencesmedicine.symptomPsychology050104 developmental & child psychology
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