0000000000154352

AUTHOR

Federica Campolo

showing 2 related works from this author

Type 5 phosphodiesterase (PDE5) and the vascular tree: from embryogenesis to aging and disease

2020

Highlights • Vascular development depends on the timely differentiation of endothelial and smooth muscle cells, that mutually influence their developmental fate. • Endothelial and vascular smooth muscle cell (VSMC) compartments can mutually influence cell and tissue modifications during vascular aging and in vascular disease. • Keeping in mind that PDE5 is mainly expressed in VSMCs, we surveyed the literature on the role of PDE5 in vascular development, aging and disease. • Although most results have been obtained by PDE5 pharmacological inhibition, no data are available, to date, on vascular development, aging or disease following PDE5 genetic ablation.

0301 basic medicineCell typeAgingVascular smooth muscleMyocytes Smooth MuscleVSMCsEmbryonic DevelopmentECsContext (language use)DiseaseBiologyMuscle Smooth VascularArticle03 medical and health sciences0302 clinical medicinenitric oxidevascular smooth muscle cellsHumansBioresorbable vascular scaffoldCyclic Nucleotide Phosphodiesterases Type 5ECEmbryogenesisPhosphodiesteraseVascular agingCell biologycGMPSettore MED/23ECs; PDE5; VSMCs; cGMP; nitric oxide030104 developmental biologyVascular aging; vascular smooth muscle cells; phosphodiesterasePDE5phosphodiesterase030217 neurology & neurosurgeryFunction (biology)Developmental Biology
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To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm

2021

In the human embryo, the genetic program that orchestrates germ cell specification involves the activation of epigenetic and transcriptional mechanisms that make the germline a unique cell population continuously poised between germness and pluripotency. Germ cell tumors, neoplasias originating from fetal or neonatal germ cells, maintain such dichotomy and can adopt either pluripotent features (embryonal carcinomas) or germness features (seminomas) with a wide range of phenotypes in between these histotypes. Here, we review the basic concepts of cell specification, migration and gonadal colonization of human primordial germ cells (hPGCs) highlighting the analogies of transcriptional/epigene…

EpigenomicsMalePluripotent Stem Cellsendocrine systemCell typeTranscription GeneticQH301-705.5PopulationReviewBiologygermlineCatalysisGermlineInorganic ChemistryTesticular Neoplasmsmedicineprimordial germ cellsHumansEpigeneticsBiology (General)Physical and Theoretical ChemistryeducationGonadsQD1-999Molecular BiologySpectroscopyeducation.field_of_studySettore BIO/16Organic ChemistryEG cellsTeratomaEmbryogerm cell tumorCell DifferentiationGeneral MedicineNeoplasms Germ Cell and Embryonalmedicine.diseaseComputer Science ApplicationsCell biologyChemistrymedicine.anatomical_structureGerm CellsExtragonadal Germ Cell TumorEG cells; germ cell tumor; germline; primordial germ cellsGerm cell tumorsGerm cell
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