0000000000160719

AUTHOR

Javier Boix-ferrero

showing 3 related works from this author

Molecular Alterations of the RBI, TP53, and MDM2 Genes in Primary and Xenografted Human Osteosarcomas

1997

We report the status of the RBI, TP53, and MDM2 genes in human osteosarcomas and cell lines established from surgical specimens and transplanted into athymic naked mice. By using reverse transcriptase-polymerase chain reaction (RT-PCR) as a prescreening technique and posterior sequencing, we observe

Primary (chemistry)Cell cultureCancer researchbiology.proteinMdm2Cell BiologyBiologyneoplasmsMolecular BiologyGenePathology and Forensic MedicineDiagnostic Molecular Pathology
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Absence of p53 gene mutations in hepatocarcinomas from a Mediterranean area of Spain

1999

The incidence of p53 gene abnormalities in human hepatocellular carcinoma (HCC) varies in different geographical areas, being higher in regions where hepatitis virus infection and dietary exposure to aflatoxin B1 are the most common aetiological agents. These mutations are less frequently encountered in Europe, although some studies have reported p53 protein overexpression in up to 45% of cases analysed. We have analysed 129 tumour samples of primary malignant hepatic neoplasms recovered from paraffin blocks processed in two pathology laboratories in a Mediterranean area of Spain (Valencia and Gerona). Among 14 cases in which p53 immunohistochemistry expression proved positive, 5 stained in…

Pathologymedicine.medical_specialtyMutationTumor suppressor geneIncidence (epidemiology)Cell BiologyGeneral MedicineGene mutationBiologymedicine.diseasemedicine.disease_causePathology and Forensic MedicineMalignant transformationExonHepatocellular carcinomamedicineMolecular BiologyGeneVirchows Archiv
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Primary Rhabdomyosarcoma Mimicking a Small Cell Sarcoma of Bone: A Nude Mice Xenograft, Cytogenetic, and Molecular Approach

1998

Small cell sarcomas of bone are difficult to classify and diagnose. The present case deals with such a tumor in which the original biopsy and the resected specimen, studied by histology before chemotherapy, provided no final information about its real nature. Thus several techniques were applied to discern its histogenesis and biology. Myogenin proved positive in isolated cells of the primary neoplasm but was extensively expressed in nude mice xenografts. Electron microscopy confirmed the existence of myofilaments. The cytogenetic analysis revealed a large number of chromo somal abnormalities, but not those found in the Ewing's/PNET (peripheral neuroectodermal tumor) family of tumors. This…

Pathologymedicine.medical_specialtymedicine.diagnostic_testPAX3Small Cell SarcomaHistologyHistogenesisBiologymedicine.diseasePrimary NeoplasmPathology and Forensic MedicineBiopsymedicineNeoplasmSurgeryAnatomyRhabdomyosarcomaInternational Journal of Surgical Pathology
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