0000000000161168
AUTHOR
R. Süsskind
Oxygen Diffusion Constants D and K of Tumor Tissue (DS-Carcinosarcoma) and Their Temperature Dependence
To understand more thoroughly the tumor O2 supply conditions, knowledge of O2 diffusivity in tumor tissue is required. Since exact measurements of the O2 diffusion constants of tumor tissue have not been carried out to date, previous investigations of tumor O2 supply had to employ estimated values (6 – 8, 10). The results of these studies are in part contradictory.
Oxygen diffusivity in tumor tissue (DS-Carcinosarcoma) under temperature conditions within the range of 20?40�C
The O2 diffusion constants D and K of tumor tissue (DS-Carcinosarcoma in the rat kidney) were determined at temperatures of 20, 30, 37, and 40 degrees C. The following mean values were obtained for the conditions of 37 degrees C: D = 1.75-10(-5) cm2/s and K = 1.9-10(-5) mlO2/cm-min-atm. Within the range of 20-40 degrees C, temperature variations in tumor tissue cause changes in the O2 diffusion coefficient D of 2.0-2.5%/C and in the Krogh O2 diffusion constant K of 0.5-1.5%/C. The measured O2 diffusion constants for tumor tissue correspond to values of normal tissue with similar water content. This indicates that the insufficient O2 supply in DS-Carcinosarcoma is due not to unfavorable O2 d…