0000000000161378
AUTHOR
T Reichert
showing 2 related works from this author
145 Multifunction Role of Osteonectin/SPARC during Human embryonic and Feta Development
1991
The temporal and spatial distribution of osteonectin/SPARC was investigated during different stages of human development by in situ hybridization and histochemistry Specific mRNA was associated with(a) tissues exhibiting high rates of matrix production (skin, vessels, tendons fetal mesenchyme), (b) cells involved in the process of mineralization (osteoblasts, chondrocytes, odontoblasts), (c)production of basement membranes (glomeruli and (d) steroid synthesis (adrenal gland, Leydig cells) In the growth plate, expression was found in the upper hypertrophic and proliferative but not in the mineralized zone. Histochemistry detected osteonectin extra-cellularly in mineralized tissues, whereas o…
Distribution of osteonectin mRNA and protein during human embryonic and fetal development.
1992
We investigated the temporal and spatial distribution of osteonectin during human embryonic and fetal development, using in situ hybridization and immunohistochemistry. Osteonectin gene expression was generally found in cells exhibiting high rates of matrix production/proliferation. In mineralized tissue, a strong signal was obtained in osteoblasts, odontoblasts, and chondrocytes of the upper hypertrophic and proliferative zones. Chondrocytes of the mineralized zone showed no expression throughout the different stages of development. Strong osteonectin expression was found in odontoblasts of developing teeth. In addition, osteonectin mRNA and protein were detected in several non-mineralize…