Author: Ivan Borrello

0000000000162137

AUTHOR

Ivan Borrello

showing 2 related works from this author

The bone marrow stroma in hematological neoplasms—a guilty bystander

2011

In the setting of hematological neoplasms, changes in the bone marrow (BM) stroma might arise from pressure exerted by the neoplastic clone in shaping a supportive microenvironment, or from chronic perturbation of the BM homeostasis. Under such conditions, alterations in the composition of the BM stroma can be profound, and could emerge as relevant prognostic factors. In this Review, we delineate the multifaceted contribution of the BM stroma to the pathobiology of several hematological neoplasms, and discuss the impact of stromal modifications on the natural course of these diseases. Specifically, we highlight the involvement of BM stromal components in lymphoid and myeloid malignancies, a…

Pathologymedicine.medical_specialtyMyeloidStromal cellbusiness.industrymedicine.diseaseArticleLymphomaBone marrow stroma hematological neoplasmsmedicine.anatomical_structureOncologyStromaBone MarrowHematologic NeoplasmsmedicineBystander effectAnimalsHumansHematological neoplasmBone marrowStromal CellsbusinessHomeostasisNature Reviews Clinical Oncology

researchProduct

FlowCT for the analysis of large immunophenotypic data sets and biomarker discovery in cancer immunology

2022

Key Points FlowCT is a new computational workspace for unveiling cellular diversity and objectively identifying biomarkers in large immune monitoring studies.FlowCT identified T-cell biomarkers predictive of malignant transformation and survival in SMM and active MM data sets.

Smoldering Multiple MyelomaOncologymedicine.medical_specialtyImmunobiology and ImmunotherapyT cellMyeloma2423ImmunophenotypingImmune systemMaintenance therapyBone MarrowInternal medicineHumansMedicineBiomarker discoveryMultiple myelomaCancer immunologybusiness.industryHematologymedicine.diseaseFlow Cytometrymedicine.anatomical_structureSmouldering myelomaBone marrowbusinessBiomarkersmyeloma flow cytometry single cell smouldering myeloma

researchProduct

PEPhysical Sciences and Engineering
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LSLife Sciences
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SHSocial Sciences and Humanities
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