A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts

OBJECTIVE: The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis. METHOD: Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (<13 years of age) from nine population-based cohorts. SNP-based heritability was estimated in data from the three largest cohorts. Meta-analysis based on genome-wide association (GWA) analyses w…

319: Single shot spinal anaesthesia with low dose hyperbaric bupivacaine (3.75 mg), for hip fracture repair surgery in the elderly

Improving Pattern Recognition Based Pharmacological Drug Selection Through ROC Analysis

The design of new medical drugs is a very complex process in which combinatorial chemistry techniques are used. The goal consists of discriminating between molecular compounds exhibiting or not certain pharmacological activities. Different machine learning approaches have been recently applied to different drug design problems leading to competitive results in pointing at particular compounds with high probability of exhibiting activity. The present work first deeps into the natural trade-off between accuracy in the much less populated active group and false alarm rate which could lead to too many expensive laboratory tests. Preliminary results show how different classification techniques a…