0000000000164459
AUTHOR
Ségolène Gaillard
Multi-omics profiling reveals that eating difficulties developed consecutively to artificial nutrition in the neonatal period are associated to specific saliva composition.
Prolonged enteral or parenteral nutrition in neonatal periods sometimes results in eating difficulties persisting for years, with reduced food intake through the oral route and thereby reduced stimulation of the oral cavity. Aiming at describing the consequences on oral physiology, saliva of 21 children with eating difficulties (ED) was compared to that of 23 healthy controls, using various omics and targeted methods. Overall, despite heterogeneity within the groups (age, medication etc.), the three spectral methods (MALDI-TOF, SELDI-TOF, (1)H NMR) allowed discriminating ED and controls, confirming that oral stimulation by food intake plays a role in shaping the composition of saliva. Saliv…
Associations between food consumption patterns and saliva composition: Specificities of eating difficulties children
Identifying objective markers of dietwould be beneficial to research fields such as nutritional epidemiology. As a preliminary study on the validity of using saliva for this purpose, and in order to explore the relationship between saliva and diet, we focused on clearly contrasted groups of children: children with eating difficulties (ED) receiving at least 50% of their energy intake through artificial nutrition vs healthy controls (C). Saliva of ED and C children was analyzed by various methods (targeted biochemical analyses, 2-D electrophoresis coupled to MS, 1H NMR) and their diet was characterized using food frequency questionnaires, considering 148 food items grouped into 13 categories…
Essais cliniques institutionnels : quel monitoring ?
Resume Objectif Les promoteurs assument la responsabilite de la qualite des essais cliniques. Ces methodes d’assurance qualite doivent etre les plus efficaces possible, et avoir un cout maitrise. Nous voulions decrire les erreurs les plus frequentes, a partir de la litterature, leur impact sur les resultats, et proposer les strategies de monitoring les plus efficientes. Resultats Les defauts rencontres concernent la conception, les procedures, la gestion des donnees et l’analyse. L’impact sur les resultats est presque toujours une surestimation de l’effet traitement. Aucune methode de monitoring n’ayant ete demontree superieure, un monitoring econome, cible sur les risques d’erreurs, avec d…
Children with eating disorders secondarily to artificial nutrition in the neonatal period have specific food preferences and saliva composition
- Objectives and studyIn the neonatal period, some severe digestive diseases require the cessation of oral feeding and the use of enteral or parenteral nutrition for prolonged periods. In some cases, this by-pass of the oral cavity during the early stages of feeding results in the development of so-called oral disorders (OD). Oral disorders may persist for years after healing of the causal disease, and are expressed for example by an exacerbated gag reflex, difficulties in chewing and swallowing and high food selectivity.The aim of this study were to describe the consequences on oral physiology of oral by-pass and enteral nutrition in a population of 21 children who suffered oral disorder (…
Oral sphere: salivary markers and food. A prospective study on children expressing oral disorders
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