0000000000164540
AUTHOR
Jie Liu
A Machine Learning Model to Predict Intravenous Immunoglobulin-Resistant Kawasaki Disease Patients: A Retrospective Study Based on the Chongqing Population
Objective: We explored the risk factors for intravenous immunoglobulin (IVIG) resistance in children with Kawasaki disease (KD) and constructed a prediction model based on machine learning algorithms.Methods: A retrospective study including 1,398 KD patients hospitalized in 7 affiliated hospitals of Chongqing Medical University from January 2015 to August 2020 was conducted. All patients were divided into IVIG-responsive and IVIG-resistant groups, which were randomly divided into training and validation sets. The independent risk factors were determined using logistic regression analysis. Logistic regression nomograms, support vector machine (SVM), XGBoost and LightGBM prediction models wer…
Study ofe+e−→ωχcJat Center of Mass Energies from 4.21 to 4.42 GeV
Based on data samples collected with the BESIII detector at the BEPCII collider at nine center of mass energies from 4.21 to 4.42 GeV, we search for the production of e(+)e(-) -> omega chi(cJ) (J = 0, 1, 2). The process e(+)e(-) -> omega chi(c0) is observed for the first time, and the Born cross sections at root s = 4.23 and 4.26 GeV are measured to be (55.4 +/- 6.0 +/- 5.9) and (23.7 +/- 5.3 +/- 3.5) pb, respectively, where the first uncertainties are statistical and the second are systematic. The omega chi(c0) signals at the other seven energies and the e(+)e(-) -> omega chi(c1) and omega chi(c2) signals are not significant, and the upper limits on the cross sections are determined. By ex…
The on-orbit calibration of DArk Matter Particle Explorer
Abstract The DArk Matter Particle Explorer (DAMPE), a satellite-based cosmic ray and gamma-ray detector, was launched on December 17, 2015, and began its on-orbit operation on December 24, 2015. In this work we document the on-orbit calibration procedures used by DAMPE and report the calibration results of the Plastic Scintillator strip Detector (PSD), the Silicon-Tungsten tracKer-converter (STK), the BGO imaging calorimeter (BGO), and the Neutron Detector (NUD). The results are obtained using Galactic cosmic rays, bright known GeV gamma-ray sources, and charge injection into the front-end electronics of each sub-detector. The determination of the boundary of the South Atlantic Anomaly (SAA…
Precision measurement of the D*(0) decay branching fractions
WOS: 000349437800001
Search for gamma-ray spectral lines with the DArk Matter Particle Explorer
The DArk Matter Particle Explorer (DAMPE) is well suitable for searching for monochromatic and sharp $\gamma$-ray structures in the GeV$-$TeV range thanks to its unprecedented high energy resolution. In this work, we search for $\gamma$-ray line structures using five years of DAMPE data. To improve the sensitivity, we develop two types of dedicated data sets (including the BgoOnly data which is the first time to be used in the data analysis for the calorimeter-based gamma-ray observatories) and adopt the signal-to-noise ratio optimized regions of interest (ROIs) for different DM density profiles. No line signals or candidates are found between 10 and 300 GeV in the Galaxy. The constraints o…
Direct detection of a break in the teraelectronvolt cosmic-ray spectrum of electrons and positrons
High energy cosmic ray electrons plus positrons (CREs), which lose energy quickly during their propagation, provide an ideal probe of Galactic high-energy processes and may enable the observation of phenomena such as dark-matter particle annihilation or decay. The CRE spectrum has been directly measured up to $\sim 2$ TeV in previous balloon- or space-borne experiments, and indirectly up to $\sim 5$ TeV by ground-based Cherenkov $\gamma$-ray telescope arrays. Evidence for a spectral break in the TeV energy range has been provided by indirect measurements of H.E.S.S., although the results were qualified by sizeable systematic uncertainties. Here we report a direct measurement of CREs in the …
Measurement of the cosmic ray proton spectrum from 40 GeV to 100 TeV with the DAMPE satellite
DAMPE satellite has directly measured the cosmic ray proton spectrum from 40 GeV to 100 TeV and revealed a new feature at about 13.6 TeV.
Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice
Diet-induced obesity is associated with fatty liver, insulin resistance, leptin resistance, and changes in plasma lipid profile. Endocannabinoids have been implicated in the development of these associated phenotypes, because mice deficient for the cannabinoid receptor CB1 (CB1-/-) do not display these changes in association with diet-induced obesity. The target tissues that mediate these effects, however, remain unknown. We therefore investigated the relative role of hepatic versus extrahepatic CB1 receptors in the metabolic consequences of a high-fat diet, using liver-specific CB1 knockout (LCB1-/-) mice. LCB1(-/-) mice fed a high-fat diet developed a similar degree of obesity as that of …
Paracrine Activation of Hepatic CB1 Receptors by Stellate Cell-Derived Endocannabinoids Mediates Alcoholic Fatty Liver
SummaryAlcohol-induced fatty liver, a major cause of morbidity, has been attributed to enhanced hepatic lipogenesis and decreased fat clearance of unknown mechanism. Here we report that the steatosis induced in mice by a low-fat, liquid ethanol diet is attenuated by concurrent blockade of cannabinoid CB1 receptors. Global or hepatocyte-specific CB1 knockout mice are resistant to ethanol-induced steatosis and increases in lipogenic gene expression and have increased carnitine palmitoyltransferase 1 activity, which, unlike in controls, is not reduced by ethanol treatment. Ethanol feeding increases the hepatic expression of CB1 receptors and upregulates the endocannabinoid 2-arachidonoylglycer…
Precise Measurement of the e+e−→π+π−J/ψ Cross Section at Center-of-Mass Energies from 3.77 to 4.60 GeV
The cross section for the process e(+)e(-)-> pi(+) pi(-) J/psi is measured precisely at center-of-mass energies from 3.77 to 4.60 GeV using 9 fb(-1) of data collected with the BESIII detector operating at the BEPCII storage ring. Two resonant structures are observed in a fit to the cross section. The first resonance has a mass of (222.0 +/- 3.1 +/- 1.4) MeV/ c(2) and a width of (44.1 +/- 4.3 +/- 2.0)MeV, while the second one has a mass of (4320.0 +/- 10.4 +/- 7.0)MeV/c(2) and a width of (101.4(- 19.7)(+25.3) +/- 10.2) MeV, where the first errors are statistical and second ones are systematic. The first resonance agrees with the Y(4260) resonance reported by previous experiments. The precisi…
The DArk Matter Particle Explorer mission
The DArk Matter Particle Explorer (DAMPE), one of the four scientific space science missions within the framework of the Strategic Pioneer Program on Space Science of the Chinese Academy of Sciences, is a general purpose high energy cosmic-ray and gamma-ray observatory, which was successfully launched on December 17th, 2015 from the Jiuquan Satellite Launch Center. The DAMPE scientific objectives include the study of galactic cosmic rays up to $\sim 10$ TeV and hundreds of TeV for electrons/gammas and nuclei respectively, and the search for dark matter signatures in their spectra. In this paper we illustrate the layout of the DAMPE instrument, and discuss the results of beam tests and calib…
Observation ofη′→ωe+e−
Based on a sample of eta' mesons produced in the radiative decay J/psi -> gamma eta' in 1.31 x 10(9) J/psi events collected with the BESIII detector, the decay eta' -> omega e(+)e(-) is observed for the first time, with a statistical significance of 8 sigma. The branching fraction is measured to be B(eta' -> omega e(+)e(-)) = (1.97 +/- 0.34(stat) +/- 0.17(syst)) x 10(-4), which is in agreement with theoretical predictions. The branching fraction of eta' -> omega gamma is also measured to be (2.55 +/- 0.03(stat) +/- 0.16(syst)) x 10(-2), which is the most precise measurement to date, and the relative branching fraction B(eta' -> omega e(+)e(-))/B(eta' -> omega gamma) is determined to be (7.7…
Elastic Superhydrophobic and Photocatalytic Active Films Used as Blood Repellent Dressing.
Durable and biocompatible superhydrophobic surfaces are of significant potential use in biomedical applications. Here, a nonfluorinated, elastic, superhydrophobic film that can be used for medical wound dressings to enhance their hemostasis function is introduced. The film is formed by titanium dioxide nanoparticles, which are chemically crosslinked in a poly(dimethylsiloxane) (PDMS) matrix. The PDMS crosslinks result in large strain elasticity of the film, so that it conforms to deformations of the substrate. The photocatalytic activity of the titanium dioxide provides surfaces with both self-cleaning and antibacterial properties. Facile coating of conventional wound dressings is demonstra…
Measurement of thee+e−→ηJ/ψcross section and search fore+e−→π0J/ψat center-of-mass energies between 3.810 and 4.600 GeV
Using data samples collected with the BESIII detector operating at the BEPCII collider at 17 center-of-mass energies from 3.810 to 4.600 GeV, we perform a study of e(+)e(-) -> eta J/psi and pi(0)J/psi The Born cross sections of these two processes are measured at each center-of-mass energy. The measured energy-dependent Born cross section for e(+)e(-) -> eta J/psi shows an enhancement around 4.2 GeV. The measurement is compatible with an earlier measurement by Belle.
Measurements of the absolute branching fractions forDs+→ηe+νeandDs+→η′e+νe
By analyzing 482 pb(-1) of e(+)e(-) collision data collected at root s = 4.009 GeV with the BESIII detector at the BEPCII collider, we measure the absolute branching fractions for the semileptonic decays D-s(+) -> eta e(+)nu(e) and D-s(+) -> eta ' e(+)nu(e) to be B(D-s(+) -> eta e(+)nu(e)) = (2.30 +/- 0.31 +/- 0.08)% and B(D-s(+) -> eta ' e(+)nu(e)) = (0.93 +/- 0.30 +/- 0.05)%, respectively, and their ratio B(D-s(+) -> eta ' e(+)nu(e)) / B(D-s(+) -> eta ' e(+)nu(e)) = 0.40 +/- 0.14 +/- 0.02, where the first uncertainties are statistical and the second ones are systematic. The results are in good agreement with previous measurements within uncertainties; they can be used to determine the eta…
Precise Measurement of the e+e− → π+π−J/ψ Cross Section at Center-of-Mass Energies from 3.77 to 4.60 GeV
The cross section for the process e(+)e(-)-> pi(+) pi(-) J/psi is measured precisely at center-of-mass energies from 3.77 to 4.60 GeV using 9 fb(-1) of data collected with the BESIII detector operating at the BEPCII storage ring. Two resonant structures are observed in a fit to the cross section. The first resonance has a mass of (222.0 +/- 3.1 +/- 1.4) MeV/ c(2) and a width of (44.1 +/- 4.3 +/- 2.0)MeV, while the second one has a mass of (4320.0 +/- 10.4 +/- 7.0)MeV/c(2) and a width of (101.4(- 19.7)(+25.3) +/- 10.2) MeV, where the first errors are statistical and second ones are systematic. The first resonance agrees with the Y(4260) resonance reported by previous experiments. The precisi…
Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice
Background and purpose Gastrointestinal (GI) motility is regulated in part by fatty acid ethanolamides (FAEs), including the endocannabinoid (EC) anandamide (AEA). The actions of FAEs are terminated by fatty acid amide hydrolase (FAAH). We investigated the actions of the novel FAAH inhibitor AM3506 on normal and enhanced GI motility. Experimental approach We examined the effect of AM3506 on electrically-evoked contractility in vitro and GI transit and colonic faecal output in vivo, in normal and FAAH-deficient mice treated with saline or LPS (100 µg·kg(-1), i.p.), in the presence and absence of cannabinoid (CB) receptor antagonists. mRNA expression was measured by quantitative real time-PCR…