0000000000172853

AUTHOR

Scutari R

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Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b

2021

HCV is an important cause of hepatocellular carcinoma (HCC). HCV NS5A domain-1 interacts with cellular proteins inducing pro-oncogenic pathways. Thus, we explore genetic variations in NS5A domain-1 and their association with HCC, by analyzing 188 NS5A sequences from HCV genotype-1b infected DAA-naïve cirrhotic patients: 34 with HCC and 154 without HCC. Specific NS5A mutations significantly correlate with HCC: S3T (8.8% vs. 1.3%, p = 0.01), T122M (8.8% vs. 0.0%, p &lt

hepatitis C virusLiver CirrhosisMaleCirrhosisvirusesHepacivirusViral Nonstructural ProteinsNS5Amedicine.disease_causeSeverity of Illness Indexgenetic variabilityMedicineLiver Neoplasmsvirus diseaseshepatocellular carcinomaMiddle AgedHepatitis CQR1-502Infectious DiseasesHepatocellular carcinomaHCVHost-Pathogen InteractionsFemaleDisease SusceptibilityCarcinoma HepatocellularGenotypeHepatitis C virusViremiaMicrobiologyArticleStructure-Activity RelationshipVirologyGenetic variationHumansGenetic variabilityNS5AneoplasmsAgedbusiness.industrycirrhosisSequence Analysis DNAbiochemical phenomena metabolism and nutritiongenotype 1bmedicine.diseaseSettore MED/17digestive system diseasesMutationCancer researchbusinessCarcinogenesisBiomarkersViruses
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