6533b7d2fe1ef96bd125e13e

RESEARCH PRODUCT

Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b

Alkhatib MDi Maio VcDe Murtas VPolilli EMilana MTeti EFiorentino GCalvaruso VBarbaliscia SBertoli AScutari RCarioti LCento VSantoro MmOrro AMaida ILenci ISarmati LCraxi APasquazzi CParruti GBabudieri SMilanesi LAndreoni MAngelico MPerno CfCeccherini-silberstein FSvicher VSalpini ROn Behalf Of Hirma Hepatocarcinoma Innovative Research Markers And Fondazione Vironet C Hcv Virology Italian Resistance.

subject

hepatitis C virusLiver CirrhosisMaleCirrhosisvirusesHepacivirusViral Nonstructural ProteinsNS5Amedicine.disease_causeSeverity of Illness Indexgenetic variabilityMedicineLiver Neoplasmsvirus diseaseshepatocellular carcinomaMiddle AgedHepatitis CQR1-502Infectious DiseasesHepatocellular carcinomaHCVHost-Pathogen InteractionsFemaleDisease SusceptibilityCarcinoma HepatocellularGenotypeHepatitis C virusViremiaMicrobiologyArticleStructure-Activity RelationshipVirologyGenetic variationHumansGenetic variabilityNS5AneoplasmsAgedbusiness.industrycirrhosisSequence Analysis DNAbiochemical phenomena metabolism and nutritiongenotype 1bmedicine.diseaseSettore MED/17digestive system diseasesMutationCancer researchbusinessCarcinogenesisBiomarkers

description

HCV is an important cause of hepatocellular carcinoma (HCC). HCV NS5A domain-1 interacts with cellular proteins inducing pro-oncogenic pathways. Thus, we explore genetic variations in NS5A domain-1 and their association with HCC, by analyzing 188 NS5A sequences from HCV genotype-1b infected DAA-naïve cirrhotic patients: 34 with HCC and 154 without HCC. Specific NS5A mutations significantly correlate with HCC: S3T (8.8% vs. 1.3%, p = 0.01), T122M (8.8% vs. 0.0%, p &lt

yearjournalcountryeditionlanguage
2021-04-01Viruses
https://doi.org/10.3390/v13050743