0000000000172878
AUTHOR
H. P. Baum
Cytoplasmic microvesicles in chromophobe cell renal carcinoma demonstrated by freeze fracture
In the chromophobe cell type of renal carcinoma, cytoplasmic microvesicles (frequently with "inner vesicles") demonstrable by transmission electron microscopy are one of the most important diagnostic features. The present paper reports on these microvesicles in freeze fracture replicas. Their diameter is mainly between 140 and 300 micron, but smaller and very much larger vesicles may also occur. The vesicle membrane is devoid of, or contains only scanty intramembranous particles. Cytoplasmic invaginations, probably the precursors of "inner vesicles" can also be detected. Connections with the agranular endoplasmic reticulum, mitochondria or other cell components could not be documented. Larg…
Evaluation of low dose anaphylatoxic peptides in the pathogenesis of the adult respiratory distress syndrome (ARDS). Monitoring of early C5a effects in a guinea-pig in vivo model after i.v. application
A guinea-pig in vivo model is presented that allows the infusion of purified C5a via a central vein catheter and the monitoring of its effects on granulocytes and platelets, the most important cells in the pathogenesis of several lung disorders, e.g. shock lung. After the infusion of C5a, which was adjusted to a quantity that caused slight and transient alterations of lung physiology, granulocytes disappeared from circulation within 1 min. Simultaneously the granulocyte content of the lung increased about three-fold as judged by histological evaluations. Morphologic destructions were not observed. After the drop a rebound of circulating Polymorpho-nuclear leucocytes (PMN) occurred, which wa…
Development of Bladder Carcinoma Following Portacaval Shunt in Rats
Portacaval anastomosis (PCA) was first introduced by Eck (1877) and was investigated in a number of different animals. Lee et al. (1961; 1974) published a reliable method with low mortality in rats. The occurrence of urolithiasis in rats following portacaval anastomosis happened to be noticed by chance. It was published by Herz et al. (1972a, 1972b, 1973), who defined the portacaval shunt rat as an experimental model. Heine et al. (1979) described dysplastic and neoplastic changes of the bladder mucosa following portacaval anastomosis. His findings were confirmed by Duy et al. (1981); Grun et al. (1982), and Dubuisson et al. (1984). However, Wallace et al. (1984) found papillary hyperplasia…
Chromophobe cell renal carcinoma and its variants--a report on 32 cases.
This paper reports on 32 chromophobe cell renal carcinomas observed in 697 renal cell cancers (RCC) of adults (peak in the sixth decade of life). The chromophobe cell-type differs from other types of RCC macroscopically, the cut-surface being predominantly of grey-beige colour. Histologically, there are two variants: one is the typical (light) variant (n = 22) and the other is eosinophilic (n = 10). Both variants have in common (a) reaction of the cytoplasm with Hale's acid iron colloid; (b) electron microscopic detection of cytoplasmic microvesicles (150-300 nm), frequently with 'inner vesicles', and (c) low glycogen content in comparison with the clear cell carcinoma. Immunocytochemical i…
Urticaria, Abdominalschmerzen, Arthritis, Pseudotumor cerebri und nephrotisches Syndrom bei 20jähriger Patientin
Mit 19 Jahren wurde die iranisch-deutsche Patientin im Oktober 1984 wegen einer Coombs-positiven hamolytischen Anamie behandelt. IgG-typische, nichtspezifische Antikorper wurden nachgewiesen. Zuvor war wegen eines grippalen Infektes ein Kombinationsmedikament verordnet worden, das Brompheniramin, Kalziumascorbat, Prophyphenazon, Salizylamid, Chini-din-Hydrochlorid und Coffein (Ilvico®) enthielt. Spezifische Antikorper gegen diese Substanzen waren nicht gesucht worden. Der Coombs-Test blieb 5 Monate positiv. Eine Corticoid-Therapie wurde mit Erfolg klinisch begonnen, von der Patientin wahrscheinlich jedoch nicht konsequent fortgesetzt. Antinukleare Antikorper waren nicht nachweisbar.