0000000000173823

AUTHOR

B. M. Hoelper

showing 3 related works from this author

Effects of a small acute subdural hematoma following traumatic brain injury on neuromonitoring, brain swelling and histology in pigs.

2011

An acute subdural hematoma (ASDH) induces pathomechanisms which worsen outcome after traumatic brain injury, even after a small hemorrhage. Synergistic effects of a small ASDH on brain damage are poorly understood, and were studied here using neuromonitoring for 10 h in an injury model of controlled cortical impact (CCI) and ASDH. Pigs (n = 32) were assigned to 4 groups: sham, CCI (2.5 m/s), ASDH (2 ml) and CCI + ASDH. Intracranial pressure was significantly increased above sham levels by all injuries with no difference between groups. CCI and ASDH reduced ptiO<sub>2</sub> by a maximum of 36 ± 9 and 26 ± 11%, respectively. The combination caused a 31 ± 11% drop. ASDH alone and i…

MaleMicrodialysisanimal structuresIntracranial PressureTraumatic brain injurySus scrofaGlutamic AcidBrain EdemaBrain damageEvoked Potentials SomatosensorymedicineAnimalsHematoma Subdural AcuteLactic AcidIntracranial pressureMonitoring Physiologicbusiness.industryGlutamate receptorHistologymedicine.diseasenervous system diseasesDisease Models AnimalSomatosensory evoked potentialAnesthesiaBrain InjuriesCerebrovascular CirculationSurgerymedicine.symptombusinessAcute subdural hematomapsychological phenomena and processesEuropean surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
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Acute Subdural Hematoma in Pigs: Role of Volume on Multiparametric Neuromonitoring and Histology

2008

Traumatic brain injury (TBI) is often complicated by acute subdural hemorrhage (ASDH) with a high mortality rate. The pathophysiological mechanisms behind such an injury type and the contribution of blood to the extent of an injury remain poorly understood. Therefore, the goals of this study were to establish a porcine ASDH model in order to investigate pathomechanisms of ASDH and to compare effects induced by blood or sheer volume. Thus, we infused 2, 5, and 9 mL of blood (up to 15% of intracranial volume), and we compared a 5-mL blood and paraffin oil volume to separate out effects of extravasated blood on brain tissue. An extended neuromonitoring was applied that lasted up to 12 h after …

MicrodialysisPathologymedicine.medical_specialtyIntracranial PressureSwineTraumatic brain injuryGlutamic AcidBrain EdemaLesionOxygen ConsumptionEvoked Potentials SomatosensorymedicineAnimalsHematoma Subdural AcuteLactic AcidCerebral perfusion pressureIntracranial pressurebusiness.industryBrainSubdural hemorrhagemedicine.diseasePathophysiologyOxygenDisease Models AnimalSomatosensory evoked potentialBrain InjuriesAnesthesiaNeurology (clinical)medicine.symptombusinessJournal of Neurotrauma
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Accuracy and stability of temperature probes for intracranial application.

2004

Intracranial temperature measurement may play a pivotal role for prognosis and treatment of neurological and neurosurgical patients. For reliable clinical application, accurate temperature readings are therefore necessary. We present an independent in vitro study investigating the accuracy and stability of three temperature probes. Eight Neurovent-P Temp (RN), eight Licox temperature sensors (LT) and eight Neurotrend sensors (NT) were placed into a water bath. The temperature was increased in 3 degrees C increments from 30 to 42 degrees C before (accuracy test day 0) and after (accuracy test day 5) a long-term stability test run at 37 +/- 0.2 degrees C. The accuracy tests revealed deviation…

Stability testChemistryThermometersGeneral NeuroscienceHigh variabilityAnalytical chemistryBrainTemperature measurementStability (probability)Sensitivity and SpecificityStandard deviationBody TemperatureTest dayMeasuring instrumentIn vitro studyBiomedical engineeringJournal of neuroscience methods
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