0000000000174773
AUTHOR
Jianjun Wang
The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation.
The Ewing sarcoma family of tumors (EFT) is a group of highly malignant small round blue cell tumors occurring in children and young adults. We report here the largest genomic survey to date of 101 EFT (65 tumors and 36 cell lines). Using a combination of whole genome sequencing and targeted sequencing approaches, we discover that EFT has a very low mutational burden (0.15 mutations/Mb) but frequent deleterious mutations in the cohesin complex subunit STAG2 (21.5% tumors, 44.4% cell lines), homozygous deletion of CDKN2A (13.8% and 50%) and mutations of TP53 (6.2% and 71.9%). We additionally note an increased prevalence of the BRCA2 K3326X polymorphism in EFT patient samples (7.3%) compared …
Distance decay 2.0. A global synthesis of taxonomic and functional turnover in ecological communities
Caio Graco-Roza was funded by the Coordination for the Improvement of Higher Education Personnel (CAPES), the Carlos Chagas Filho Research Support Foundation (FAPERJ) and the Ella and Georg Erhnrooth Foundation; Jan Altman by research grants INTER-EXCELLENCE LTAUSA19137 provided by Czech Ministry of Education, Youth and Sports, 20-05840Y of the Czech Science Foundation, and long-term research development project no. RVO 67985939 of the Czech Academy of Sciences; Otso Ovaskainen was funded by Academy of Finland (grant no. 309581), Jane and Aatos Erkko Foundation, Research Council of Norway through its Centres of Excellence Funding Scheme (223257), and the European Research Council (ERC) unde…
From Well-Defined Carbon-Rich Precursors to Monodisperse Carbon Particles with Hierarchic Structures
The creation of nanoscale particles with well-defined structures has long been considered as a promising approach to generate materials with novel properties. Carbonaceous nanoparticles (CNPs) with defined architectures, such as carbon nanotubes (CNTs), C60, carbon onions, carbon spheres, and carbon rods are particularly attractive owing to their unique electronic properties and many potential applications. At the same time, when these CNPs are regularly organized, additional functions appear. Such materials are believed to have hierarchic structures, in which the organization of the CNPs forms the first-order structure (FOS) and the configuration of the single CNP forms the secondor higher…