Data set of interactomes and metabolic pathways of proteins differentially expressed in brains with Alzheimer׳s disease

Alzheimer's disease is one of the main causes of dementia in the elderly and its frequency is on the rise worldwide. It is considered the result of complex interactions between genetic and environmental factors, being many of them unknown. Therefore, there is a dire necessity for the identification of novel molecular players for the understanding of this disease. In this data article we determined the protein expression profiles of whole protein extracts from cortex regions of brains from patients with Alzheimer's disease in comparison to a normal brain. We identified 721 iTRAQ-labeled polypeptides with more than 95% in confidence. We analyzed all proteins that changed in their expression l…

P2‐077: Identification of potential modifiers of Alzheimer's disease pathology by quantitative mass spectrometry and drosophila genetics