0000000000175384
AUTHOR
M Valentini
Addition of either pioglitazone or a sulfonylurea in type 2 diabetic patients inadequately controlled with metformin alone: impact on cardiovascular events. A randomized controlled trial.
Abstract Background and aims Metformin is the first-line therapy in type 2 diabetes. In patients inadequately controlled with metformin, the addition of a sulfonylurea or pioglitazone are equally plausible options to improve glycemic control. However, these drugs have profound differences in their mechanism of action, side effects, and impact on cardiovascular risk factors. A formal comparison of these two therapies in terms of cardiovascular morbidity and mortality is lacking. The TOSCA.IT study was designed to explore the effects of adding pioglitazone or a sulfonylurea on cardiovascular events in type 2 diabetic patients inadequately controlled with metformin. Methods Multicentre, random…
ERROR AND UNCERTAINTY ANALYSIS OF RESIDUAL STRESS EVALUATION BY USINGTHE RING-CORE METHOD
The Ring-Core Method is a technique used for the experimental analysis of the residual stresses in mechanical components. For uniform and non-uniform residual stresses estimation, the use of the method leads in general to accurate results but, unfortunately at present the user does not have appropriate procedures to correct the obtained results from systematic errors as well as to estimate the uncertainty due to random errors. In order to overcome such drawbacks, in the present work, the procedures for the correction of the effects of the main error sources and for the stress uncertainty estimation, are proposed. The practical application of such procedures allow the user to highlight the r…
Pristionchus sp. (Rhabditida: Diplogastridae) from Italian populations of Anoplophora chinensis Forster (Coleoptera: Cerambycidae).
Priostonchus sp. n. (Rhabditida: Diplogastridae) is described from a population of Citrus Longhorn Beetles. Alive adults of this Cerambycid were collected from Acer saccharinum trees at Assago and Parabiago (Villastanza), two localities near Milan (Italy). The natural occurrence of the entomogenous nematode in the beetle was not frequent and widespread in the study area. Preliminary laboratory infectivity tests highlight the potential parasitic nature of the nematode. However, it was not successfully maintained in storage and culture. The diplogasterid Pristionchus sp. has rather complicate systematic thus a biomolecular analysis based on DNA is necessary for more specific identification an…
Search for eccentric binary black hole mergers with advanced LIGO and advanced Virgo during their first and second observing runs
When formed through dynamical interactions, stellar-mass binary black holes may retain eccentric orbits ($e>0.1$ at 10 Hz) detectable by ground-based gravitational-wave detectors. Eccentricity can therefore be used to differentiate dynamically-formed binaries from isolated binary black hole mergers. Current template-based gravitational-wave searches do not use waveform models associated to eccentric orbits, rendering the search less efficient to eccentric binary systems. Here we present results of a search for binary black hole mergers that inspiral in eccentric orbits using data from the first and second observing runs (O1 and O2) of Advanced LIGO and Advanced Virgo. The search uses min…
Search for Subsolar Mass Ultracompact Binaries in Advanced LIGO's Second Observing Run
We present a search for subsolar mass ultracompact objects in data obtained during Advanced LIGO’s second observing run. In contrast to a previous search of Advanced LIGO data from the first observing run, this search includes the effects of component spin on the gravitational waveform. We identify no viable gravitational-wave candidates consistent with subsolar mass ultracompact binaries with at least one component between \ud0.2\ud \ud \udM\ud⊙\ud–\ud1.0\ud \ud \udM\ud⊙\ud. We use the null result to constrain the binary merger rate of (\ud0.2\ud \ud \udM\ud⊙\ud, \ud0.2\ud \ud \udM\ud⊙\ud) binaries to be less than \ud3.7\ud×\ud10\ud5\ud \ud \udGpc\ud−\ud3\ud \udyr\ud−\ud1\udand the binary …
Increasing the Astrophysical Reach of the Advanced Virgo Detector via the Application of Squeezed Vacuum States of Light
Current interferometric gravitational-wave detectors are limited by quantum noise over a wide range of their measurement bandwidth. One method to overcome the quantum limit is the injection of squeezed vacuum states of light into the interferometer's dark port. Here, we report on the successful application of this quantum technology to improve the shot noise limited sensitivity of the Advanced Virgo gravitational-wave detector. A sensitivity enhancement of up to 3.2±0.1 dB beyond the shot noise limit is achieved. This nonclassical improvement corresponds to a 5%-8% increase of the binary neutron star horizon. The squeezing injection was fully automated and over the first 5 months of the thi…