Participation in sociolinguistic research
Involving speakers in research on their linguistic practices has been at the core of sociolinguistics since the inception of the field. In contrast to social sciences, however, sociolinguists have rarely addressed the issues surrounding the participation of those involved and engaged in the research process. This paper aims at reviewing the state of the art and outlining critical dimensions and aspects with relation to participation. We explore previous studies and study designs with the help of the following questions: Who has been involved? How and with what impact have stakeholders participated in different strands of sociolinguistic research? Current developments are presented and revie…
Improved Efficacy of Synthesizing *MIII-Labeled DOTA Complexes in Binary Mixtures of Water and Organic Solvents. A Combined Radio- and Physicochemical Study
Typically, the synthesis of radiometal-based radiopharmaceuticals is performed in buffered aqueous solutions. We found that the presence of organic solvents like ethanol increased the radiolabeling yields of [68Ga]Ga-DOTA (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacatic acid). In the present study, the effect of organic cosolvents [ethanol (EtOH), isopropyl alcohol, and acetonitrile] on the radiolabeling yields of the macrocyclic chelator DOTA with several trivalent radiometals (gallium-68, scandium-44, and lutetium-177) was systematically investigated. Various binary water (H2O)/organic solvent mixtures allowed the radiolabeling of DOTA at a significantly lower temperature than …