Mevolonate Pathway:role of bisphosphonates and statins

Cardiovascular diseases, i.e. high blood pressure, coronary heart disease, and stroke, and osteoporosis are public health problems, with several epidemiological links, and they might be related to each other in terms of pathogenesis and therapeutic agents. Bisphosphonates inhibit bone resorption and are used in the treatment of osteoporosis, whereas statins inhibit cholesterol biosynthesis and are used for the treatment of atherosclerosis and lipid metabolic disorders. Some late clinical studies suggested bisphosphonates may have beneficial effect in vivo on atherosclerotic progression, lipid profiles, and cardiovascular morbidity and mortality, whereas statins might increase bone density, …

Periodic fever: a case report.

An episode of acute cholangitis in a department of internal medicine: An unusual case

The unsolved question of acute pancreatitis. prognostic criteria: A case report

Osteoporosis in pregnancy: A case report and review of the literature

Possibile ruolo di Sch1 nel crosstalk tra i due maggiori proaging pathways

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MALATTIA OSSEA DI PAGET NELL’ANZIANO: UNA POSSIBILITÀ DIAGNOSTICA DA NON TRASCURARE

La malattia ossea di Paget è una delle principali alte-razioni del metabolismo scheletrico, seconda per frequenza solo all’osteoporosi. È caratterizzata da un di-sordine focale e progressivo del rimaneggiamento osseo, nel quale il tessuto osseo normale viene rimosso e sostituito con tessuto osseo patologico. La malattia è di solito diagnosticata in soggetti di età superiore ai 55 anni con una maggiore prevalenza nel sesso maschile. Sulla base di reperti autoptici, si è stimato che possa colpire fino al 4% dei soggetti di età superiore ai 50 anni e la probabilità che compaia aumenta con l’età con un’incidenza di circa il 10% nei soggetti molto anziani. I segni clinici vengono solitamente esp…

Atypical bartonella henselae neuroretinitis in an immunocompetent patient

We report a case of a 57-year-old immunocompetent male, admitted to our Department due to the loss of visual acuity to the right eye, occurred during the two weeks before the hospitalization, and hyperglycaemia. Our patient suffered from metabolic syndrome, characterized by visceral obesity, impaired glucose tolerance, arterial hypertension, complicated by proteinuria, and moderate grade hypertensive retinopathy. Surprisingly, and despite its many comorbidities, the final diagnosis was neuroretinitis by Bartonella henselae, without any other symptoms/signs of cat-scratch disease. The patient denied any kind of contact with cats. He was cured by specific antibiotic therapy, restoring status …