Ranolazine induced modifications of ventricular fibrillation activation complexity under mechanical stretch

P267Myocardial electrophysiological effects mediated by KATP channels: controversial aspects about their involvement in the protection by chronic exercise

Dominant frequency and complexity of electrical reentrant activation during ventricular fibrillation with releasing of NO after acute local stretching. A study in isolated rabbit heart

Effect of chronic exercise and ATP-sensitive potassium channel blockade on the spectral characteristics evolution of ventricular fibrillation in acute regional ischemia

Purpose: It has been proposed that chronic exercise produces a KATP channel blockade in ischemic myocardium. We have also reported that channel blockade and training exert very similar effects on energy required to defibrillate. In fact it is postulated that one mechanism by which exercise exerts an antiarrhythmic effect, is by blocking KATP channel. We have analyzed the evolution of spectrum characteristics of ventricular fibrillation (VF), in normoxic conditions and after acute myocardial ischemia, in isolated hearts from trained rabbits, and in hearts submitted to KATP channel blockade. Our hypothesis is that the spectrum characteristics of VF evolve similarly in trained hearts and in he…