0000000000178235

AUTHOR

J. Manyé

showing 4 related works from this author

P008 Differences in macrophage infiltration and Wnt ligands expression between stricturing and penetrating behaviour in Crohn’s disease

2018

Crohn's diseaseFrizzledbiologybusiness.industryColorectal cancermedicine.medical_treatmentGastroenterologyWnt signaling pathwayInterleukinGeneral Medicinemedicine.diseaseCytokineFibrosisCancer researchbiology.proteinMedicinebusinessInterleukin 6Journal of Crohn's and Colitis
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P041 Differences in NOTCH signalling between stricturing and penetrating behaviour in Crohn’s disease

2019

Crohn's diseasebusiness.industryGastroenterologyCancer researchNotch signaling pathwayMedicineGeneral Medicinebusinessmedicine.diseaseJournal of Crohn's and Colitis
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WNT2b activates epithelial-mesenchymal transition through FZD4: relevance in penetrating Crohns disease.

2020

Abstract Background and Aims Epithelial-mesenchymal transition [EMT] has been related to fibrosis and fistula formation, common complications associated with Crohn´s disease [CD]. The WNT signalling pathway mediates EMT, and specific WNT/FZD interactions have been related to the activation of this process in several diseases. We aim to analyse the relevance of EMT and WNT ligands and receptors in the penetrating behaviour of CD. Methods Intestinal surgical resections were obtained from control and CD patients with a stenotic or penetrating behaviour. Fibrosis was determined by the histological analysis of collagen deposition and EMT by confocal microscopy. The expression of WNT ligands, inh…

Male0301 basic medicineWNT pathwayVimentin0302 clinical medicineCrohn DiseaseFibrosisMedicineIntestinal MucosaReceptorWnt Signaling PathwayAged 80 and overbiologyGastroenterologyWnt signaling pathwayGeneral MedicineMiddle AgedCrohn's disease10219 Clinic for Gastroenterology and Hepatology030220 oncology & carcinogenesisembryonic structuresFemaleHT29 CellsAdultEpithelial-Mesenchymal TransitionAdolescentColonBlotting Western610 Medicine & healthReal-Time Polymerase Chain ReactionYoung Adult03 medical and health sciencesHT29 CellsHumansImmunoprecipitation2715 GastroenterologyEpithelial–mesenchymal transitionCrohn´s disease WNT pathway fibrosisAgedGlycoproteinsCadherinbusiness.industryfibrosismedicine.diseaseFibrosisFrizzled ReceptorsIn vitroWnt Proteins030104 developmental biologyCancer researchbiology.proteinbusiness
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P003 C86/CD16 macrophages may act as a source of WNT2b in intestinal tissue from B3 Crohn’s disease patients

2019

Crohn's diseasebusiness.industryImmunologyGastroenterologyMedicineGeneral MedicineCD16businessmedicine.diseaseJournal of Crohn's and Colitis
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