0000000000179252

AUTHOR

Corina Wilding

showing 3 related works from this author

Autoimmune biomarkers in glaucoma patients.

2013

There is growing evidence showing an autoimmune involvement in the pathogenesis of glaucoma, and that alterations in natural occurring autoantibody levels play a key role. The upregulation of autoantibodies can be associated with fatal conditions, but several studies demonstrate that natural autoantibodies entail also protective characteristics and influence the protein expression of neuroretinal cells. A disbalance of natural occurring autoantibodies may shift the physiological equilibrium of protective immunity leading to a predisposition for developing glaucoma. This article highlights recent advances in understanding of autoimmune mechanisms in the pathogenesis of glaucoma.

PharmacologyProtective immunitybusiness.industryAutoantibodyGlaucomaAutoimmunityGlaucomamedicine.diseaseProtein expressionPathogenesisDownregulation and upregulationDrug DiscoveryImmunologyProtective characteristicsmedicineAnimalsHumansbusinessBiomarkersAutoantibodiesCurrent opinion in pharmacology
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Does autoimmunity play a part in the pathogenesis of glaucoma?

2013

Glaucoma is a chronic neurodegenerative disease and one of the leading causes of blindness. Several risk factors have been described, e.g. an elevated intraocular pressure (IOP), oxidative stress or mitochondrial dysfunction. Additionally, alterations in serum antibody profiles of glaucoma patients, upregulation (e.g. anti-HSP60, anti-MBP) and downregulation (e.g. anti-14-3-3), have been described, but it still remains elusive if the autoantibodies seen in glaucoma are an epiphenomenon or causative. However, it is known that elicited autoimmunity causes retinal ganglion cell loss resulting in glaucomatous-like damage and according to the autoaggressive nature of some autoantibodies we found…

business.industryAutoantibodyGlaucomaAutoimmunityGlaucomaDiseasemedicine.diseasemedicine.disease_causeNeuroprotectionRetinaSensory SystemsAutoimmune DiseasesBiomarker (cell)AutoimmunityPathogenesisDisease Models AnimalOphthalmologyImmunologyProtective autoimmunitymedicineAnimalsHumanssense organsbusinessAutoantibodiesProgress in Retinal and Eye Research
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Neuroprotective effects of antibodies on retinal ganglion cells in an adolescent retina organ culture

2016

Glaucoma, a neurodegenerative disease, is characterized by a progressive loss of retinal ganglion cells (rgc). Up- and down-regulated autoantibody immunoreactivities in glaucoma patients have been demonstrated. Previous studies showed protective effects of down-regulated antibodies [gamma (γ)-synuclein and glial fibrillary acidic protein [GFAP]) on neuroretinal cells. The aim of this study was to test these protective antibody effects on rgc in an organ culture model and to get a better understanding of cell-cell interactions of the retina in the context of the protective effect. We used an adolescent retinal organ culture (pig) with an incubation time of up to 4 days. Retinal explants were…

MaleRetinal Ganglion Cells0301 basic medicinePathologymedicine.medical_specialtyAdolescentgenetic structuresSwineNerve Tissue ProteinsContext (language use)Organ cultureBiochemistryRetinal ganglionAntibodies03 medical and health sciencesCellular and Molecular Neurosciencechemistry.chemical_compoundOrgan Culture TechniquesGlutamate-Ammonia LigaseGlutamine synthetaseGlial Fibrillary Acidic ProteinmedicineAnimalsHumansRetinaGlial fibrillary acidic proteinbiologyMyoglobinGlaucomaRetinalEndoplasmic Reticulum StressImmunohistochemistryMolecular biologyeye diseasesNeuroprotective Agents030104 developmental biologymedicine.anatomical_structurechemistryalpha-Synucleinbiology.proteinImmunohistochemistryFemalesense organsJournal of Neurochemistry
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