6533b7d2fe1ef96bd125eafa

RESEARCH PRODUCT

Autoimmune biomarkers in glaucoma patients.

Katharina BellNadine Von Thun Und Hohenstein-blaulOliver W. GramlichCorina WildingFranz H. GrusSabine BeckNorbert Pfeiffer

subject

PharmacologyProtective immunitybusiness.industryAutoantibodyGlaucomaAutoimmunityGlaucomamedicine.diseaseProtein expressionPathogenesisDownregulation and upregulationDrug DiscoveryImmunologyProtective characteristicsmedicineAnimalsHumansbusinessBiomarkersAutoantibodies

description

There is growing evidence showing an autoimmune involvement in the pathogenesis of glaucoma, and that alterations in natural occurring autoantibody levels play a key role. The upregulation of autoantibodies can be associated with fatal conditions, but several studies demonstrate that natural autoantibodies entail also protective characteristics and influence the protein expression of neuroretinal cells. A disbalance of natural occurring autoantibodies may shift the physiological equilibrium of protective immunity leading to a predisposition for developing glaucoma. This article highlights recent advances in understanding of autoimmune mechanisms in the pathogenesis of glaucoma.

yearjournalcountryeditionlanguage
2013-02-01Current opinion in pharmacology
10.1016/j.coph.2012.09.005https://pubmed.ncbi.nlm.nih.gov/23031798