0000000000180862

AUTHOR

M Capogreco

showing 3 related works from this author

HPV infection in relation to OSCC histological grading and TNM stage. Evalutation by traditional statistics and fuzzy logic model

2006

We aimed to evaluate if in oral squamous cell carcinoma (OSCC) there is a relationship between histological grading (HG), TNM clinical stage and HPV infection; and to study the performance of fuzzy logic compared to traditional statistics, in the analysis of HPV status and correlates of OSCC. In cross-sectional analysis, the study group comprised 63 patients (mean age 68.89 years (SD ± 11.78), range (32–93); males 28 (44.4%), females 35 (55.6%)) with OSCC histologically diagnosed. HPV-DNA was studied in exfoliated oral epithelial cells by nested PCR (MY09/MY11 and GP5+/GP6+ primers). Data were analysed in parallel by traditional statistics with multivariate analysis and a fuzzy logic (FL) t…

AdultMaleCancer ResearchMultivariate analysisStage iiBiologyModels BiologicalFuzzy LogicStatisticsCarcinomamedicineHumansGrading (tumors)AgedAged 80 and overOSCC HPV-DNA GradingPapillomavirus InfectionsHPV infectionMiddle Agedmedicine.diseasestomatognathic diseasesCross-Sectional StudiesIncreased riskOncologyMultivariate AnalysisCarcinoma Squamous CellFemaleMouth NeoplasmsPrimary tumour sizeOral SurgeryStage iv
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Bcl-2 as prognostic factor in head and neck squamous cell carcinoma

2005

A series of 66 cases of oral squamous cell carcinoma (OSCC) was retrospectively analyzed by immunohisto-chemistry for bcl-2 expression to verify its predictive value for clinical outcome in patients with OSCC. After grouping for bcl-2 expression, OSCCs were statistically analyzed for the variables age, gender, histological grading (G), TNM, staging, recurrence, and overall survival rate. Univariate and multivariate (Cox regression) analyses were performed. Thirty-six OSCC (54.5%) showed expression for bcl-2, whereas 30 (44.5%) were negative. No statistical association was found between bcl-2 expression and any variables considered at baseline. Overall disease-specific survival rate at 72 mo…

AdultMaleEXPRESSIONOncologyCancer Researchmedicine.medical_specialtyPathologyAdolescentSPONTANEOUS APOPTOSISPROTEINBCL-2Internal medicinemedicineCarcinomaHumansPROGNOSTIC SIGNIFICANCEGrading (tumors)Survival rateIMMUNOHISTOCHEMICAL ANALYSISORAL-CAVITYIN-VIVOAgedRetrospective StudiesAged 80 and overProportional hazards modelbusiness.industryCancerRetrospective cohort studyGeneral MedicineMiddle AgedPrognosismedicine.diseaseImmunohistochemistryCANCERHead and neck squamous-cell carcinomaSurvival RateFAMILY-MEMBERSstomatognathic diseasesProto-Oncogene Proteins c-bcl-2OncologySQUAMOUS CELL CARCINOMAHead and Neck NeoplasmsBAXCarcinoma Squamous CellRegression AnalysisImmunohistochemistryFemalebusinessONCOPROTEIN
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Effect of c-Met expression on survival in head and neck squamous cell carcinoma

2005

The proto-oncogene c-Met has been suggested to be associated with progression of squamous cell carcinoma of the head and neck. The aims of the present study were to assess the prevalence of c-Met expression in oral squamous cell carcinoma (OSCC) and to verify whether c-Met can be considered a marker of prognosis in these patients. In a retrospective study, a cohort of 84 OSCC patients was investigated for c-Met expression and its cellular localization by immunohistochemistry. After grouping for c-Met expression, OSCC patients were statistically analyzed for the variables age, gender, histological grading, tumor node metastasis, staging and overall survival rate. Univariate and multivariate …

OncologyAdultMalemedicine.medical_specialtyc-Met; Cox regression analysis; Oral squamous cell carcinoma;C-MetAdolescentcox regression analysisProto-Oncogene Maschemistry.chemical_compoundInternal medicinemedicineBiomarkers TumorHumansBasal cellHead and neckc-MetNeoplasm Stagingbusiness.industryMouth MucosaGeneral MedicineMiddle AgedProto-Oncogene Proteins c-metmedicine.diseasePrognosisHead and neck squamous-cell carcinomaImmunohistochemistryUp-Regulationoral squamous cell carcinomastomatognathic diseaseschemistryCarcinoma Squamous CellFemaleMouth Neoplasmsbusiness
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