Early diagnosis of intravascular large B-cell lymphoma.

Acquired symmetric asymptomatic lesions at the inner corners of the eyes

Tiefes, ulzerierendes Granuloma anulare mit resultierender Funktionsstörung des Ellenbogen-Gelenks.

Pembrolizumab-induzierter Lichen planus pemphigoides bei einem Patienten mit metastasiertem Melanom

Increased risk of angiosarcoma secondary to cancer radiotherapy: Case series and review of the treatment options.

Angiosarcomas (ASs) are aggressive tumors of vascular endothelial origin, occurring sporadically or in association with prior radiotherapy or chronic lymphedema. With only 1-5% of all sarcomas, the incidence seems low, but for the affected patient due to the extremely poor prognosis and the limited treatment options, the fate is often inevitable. Radiotherapy, chemotherapy, or "target therapy" have been used in the management of AS, but represent individual case decisions without lasting evidence. Over the past few years, breast-conserving surgery followed by radiation therapy, known as breast-conserving therapy (BCT), is being employed as a standard treatment for early-stage breast cancer,…

Frühzeitige Diagnose des intravaskulären großzelligen B‐Zell‐Lymphoms

Huge pedunculated tumor of the thigh

Blistering of the hands following a manicure at a nail salon.

Pembrolizumab-induced lichen planus pemphigoides in a patient with metastatic melanoma

Immunohistochemical markers for histopathological diagnosis and differentiation of acute cutaneous graft‐versus‐host disease

Graft-versus-host disease (GvHD) is a major complication following stem-cell or solid-organ transplantation. Accurate diagnosis of cutaneous GvHD is challenging, given that drug eruptions and viral rashes may present with similar clinical/histological manifestations. Specific markers are not available. We performed the histological examination of biopsy samples from acute GvHD (aGvHD; n = 54), Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN; n = 27), maculopapular drug eruption (MDE; n = 26) and healthy controls (n = 26). Samples of aGvHD showed a decrease in Langerhans cells (LC, p = 0.0001) and an increase in macrophages (MΦ, p = 0.0001) compared to healthy skin. Compared to …

Blasenbildung an den Händen nach Maniküre in einem Nagelstudio

Asymptomatische, erworbene symmetrische Läsionen am Augeninnenwinkel