0000000000181606

AUTHOR

Fabiola Graziano

showing 3 related works from this author

Social distancing in chronic migraine during the covid-19 outbreak: Results from a multicenter observational study

2021

Background: The restrictions taken to control the rapid spread of COVID-19 resulted in a sudden, unprecedented change in people’s lifestyle, leading to negative consequences on general health. This study aimed to estimate the impact of such changes on migraine severity during 2020 March–May lockdown. Methods: Patients affected by migraine with or without aura, diagnosed by expert physicians, completed a detailed interview comprehensive of: assessment of migraine characteristics

AdultSleep Wake Disordersmedicine.medical_specialtyAuraMigraine DisordersPhysical DistancingMetabolic equivalentArticle03 medical and health sciences0302 clinical medicineChronic MigraineQuality of lifeInternal medicineSurveys and QuestionnairesEpidemiologymedicineHumansTX341-641030212 general & internal medicineExerciseLife StyleMigraineNutritionSleep disorderSleep disorderNutrition and DieteticsCOVID-19; Migraine; Nutrition; Physical activity; Quarantine; Sleep disorder; Adult; COVID-19; Communicable Disease Control; Exercise; Feeding Behavior; Headache; Humans; Italy; Life Style; Middle Aged; Migraine Disorders; Quality of Life; Quarantine; SARS-CoV-2; Sleep; Sleep Wake Disorders; Surveys and Questionnaires; Physical Distancingbusiness.industryNutrition. Foods and food supplyPhysical activitySARS-CoV-2HeadacheCOVID-19Feeding BehaviorMiddle Agedmedicine.diseaseMigraineItalyQuarantineCommunicable Disease ControlQuality of LifeObservational studySettore MED/26 - Neurologiasense organsbusinessSleep030217 neurology & neurosurgeryFood Science
researchProduct

Prognostic Role of CSF β-amyloid 1–42/1–40 Ratio in Patients Affected by Amyotrophic Lateral Sclerosis

2021

The involvement of β-amyloid (Aβ) in the pathogenesis of amyotrophic lateral sclerosis (ALS) has been widely discussed and its role in the disease is still a matter of debate. Aβ accumulates in the cortex and the anterior horn neurons of ALS patients and seems to affect their survival. To clarify the role of cerebrospinal fluid (CSF) Aβ 1–42 and Aβ 42/40 ratios as a potential prognostic biomarker for ALS, we performed a retrospective observational study on a cohort of ALS patients who underwent a lumbar puncture at the time of the diagnosis. CSF Aβ 1–40 and Aβ 1–42 ratios were detected by chemiluminescence immunoassay and their values were correlated with clinical features. We found a signi…

Pathologymedicine.medical_specialtybeta amyloidArticlelcsh:RC321-571Pathogenesis03 medical and health sciences0302 clinical medicineCerebrospinal fluidmedicineAmyotrophic lateral sclerosislcsh:Neurosciences. Biological psychiatry. Neuropsychiatry030304 developmental biology0303 health sciencesMini–Mental State Examinationmedicine.diagnostic_testLumbar puncturebusiness.industryGeneral Neurosciencebiomarker.Retrospective cohort studymedicine.diseaseCortex (botany)Biomarker (medicine)biomarkerALSbusiness030217 neurology & neurosurgeryBrain Sciences
researchProduct

Biomarkers Related to Synaptic Dysfunction to Discriminate Alzheimer’s Disease from Other Neurological Disorders

2022

Recently, the synaptic proteins neurogranin (Ng) and α-synuclein (α-Syn) have attracted scientific interest as potential biomarkers for synaptic dysfunction in neurodegenerative diseases. In this study, we measured the CSF Ng and α-Syn concentrations in patients affected by AD (n = 69), non-AD neurodegenerative disorders (n-AD = 50) and non-degenerative disorders (n-ND, n = 98). The concentrations of CSF Ng and α-Syn were significantly higher in AD than in n-AD and n-ND. Moreover, the Aβ42/Ng and Aβ42/α-Syn ratios showed statistically significant differences between groups and discriminated AD patients from n-AD patients, better than Ng or α-Syn…

Alzheimer’s disease; biomarkers; neurogranin; α-synucleinAmyloid beta-PeptidesneurograninOrganic ChemistrybiomarkersNeurodegenerative Diseasestau ProteinsGeneral MedicineCatalysisSettore MED/01 - Statistica MedicaComputer Science ApplicationsInorganic Chemistryα-synucleinAlzheimer DiseaseFluorodeoxyglucose F18alpha-SynucleinHumansCognitive DysfunctionSettore MED/26 - NeurologiaPhysical and Theoretical ChemistryAlzheimer’s diseaseMolecular BiologySpectroscopyInternational Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10831
researchProduct