0000000000181957

AUTHOR

Giuseppina Raffa

showing 2 related works from this author

Virological profiles in patients with chronic hepatitis C and overt or occult HBV infection

2002

Abstract OBJECTIVES: The virological profiles of hepatitis B and C viruses (HBV and HCV) and their interplay in cases of coinfection are undefined. A suppressed and occult HBV infection may occur in hepatitis B surface antigen (HBsAg) negative patients with chronic hepatitis C. The HCV core protein is able to inhibit HBV “in vitro,” and serines at positions 99 and 116 are essential for such inhibition. We aimed to assess the HBV and HCV virological profiles in cases of coinfection and to evaluate the relationship between HCV core gene variability and HBV activity. METHODS: Eighty-two anti-HCV positive patients were examined: 35 cases were HBsAg positive, 24 were HBsAg negative with “occult”…

AdultMaleHepatitis B virusHBsAgHCV RNAHepacivirusHepatitis C virusDUAL INFECTION; INTERFERON THERAPY; HEPATOCELLULAR-CARCINOMA; CHRONIC LIVER-DISEASE; HCV core protein; Hepatitis B Surface Antigens; HCV RNAGenome ViralHepacivirusDUAL INFECTIONVirus Replicationmedicine.disease_causeCHRONIC LIVER-DISEASEHepatitis B ChronicINTERFERON THERAPYOrthohepadnavirusHEPATOCELLULAR-CARCINOMAmedicineHumansAgedHepatitis B virusHepatitis B Surface AntigensHepatologybiologybusiness.industryHCV core proteinGastroenterologyvirus diseasesHepatitis C ChronicMiddle AgedViral LoadHepatitis Bbiology.organism_classificationmedicine.diseaseVirologydigestive system diseasesHepadnaviridaeDNA ViralImmunologyCoinfectionRNA ViralFemalebusinessThe American Journal of Gastroenterology
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Hepatitis B virus maintains its pro-oncogenic properties in the case of occult HBV infection.

2003

Background & Aims: Occult hepatitis B virus (HBV) infection is characterized by persistence of HBV DNA into the tissue of hepatitis B surface antigen-negative individuals. The clinical relevance of this peculiar infection is still under debate. In particular, the impact of occult HBV infection in cases of hepatocellular carcinoma (HCC) is uncertain. We investigated the prevalence and molecular status of occult HBV in patients with HCC. Methods: We tested tumor tissues from 107 patients with HCC and the corresponding nontumor liver tissue from 72 of these patients for HBV DNA. We also examined liver specimens from 192 patients with chronic hepatitis. All cases were hepatitis B surface antige…

MaleHBV; HCC; occultHepatitis B virusCarcinoma HepatocellularOCCULT HEPATITIS B VIRUS INFECTION; HEPATOCELLULAR CARCINOMA; HBV DNA; TUNOR AND NONTUMOR LIVER TISSUES; HBV TRANSCRIPTS; HBV COVALENTLY CLOSED CIRCULAR DNA; INTEGRATED AND EPISOMAL HBV DNATranscription GeneticOCCULT HEPATITIS B VIRUS INFECTIONHBV TRANSCRIPTSGenome ViralBiologyVirus Replicationmedicine.disease_causeChronic liver diseaseHepatitis B ChronicmedicineCarcinomaHBVHumansHEPATOCELLULAR CARCINOMATUNOR AND NONTUMOR LIVER TISSUESHCCAgedHepatitis B virusHepatologyINTEGRATED AND EPISOMAL HBV DNALiver NeoplasmsGastroenterologyvirus diseasescccDNAMiddle AgedHepatitis Bmedicine.diseaseOccultVirologydigestive system diseaseshepatitis B surface antigenLiverViral replicationHBV DNAoccultHepatocellular carcinomaDNA ViralImmunologyFemaleHBV COVALENTLY CLOSED CIRCULAR DNAInfection OBI
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