0000000000185604
AUTHOR
Luis Such-belenguer
Synchrony Analysis of Unipolar Cardiac Mapping during Ventricular Fibrillation
Ventricular Fibrillation (VF) is one of the main causes of death in developed countries. Recent studies have shown that fibrillation have a complex organization scheme. This work uses three measures of synchrony to characterize three groups of rabbit hearts. These groups consist of rabbits trained with physical exercise (N=7), untrained rabbits treated with a drug (N=13) and a control group of untrained rabbits (N=15). Cardiac mapping records were acquired using a 240-electrode array placed on left ventricle of isolated rabbit hearts, and VF was induced pacing at increasing rates. Two acquisitions were performed: maintained perfusion, and ischemic damage produced by an artery ligation. The …
Modelos animales de enfermedad cardiovascular
La utilizacion de modelos animales para el estudio de enfermedades cardiovasculares ha contribuido sustancialmente al progreso en el conocimiento de su patogenia y ha permitido el desarrollo de tecnicas diagnosticas y la validacion de procedimientos preventivos y terapeuticos, tanto farmacologicos como intervencionistas. Las diferencias existentes entre la enfermedad humana y la inducida experimentalmente, tanto en los mecanismos de regulacion genetica como en los factores que determinan la funcion cardiaca y vascular, son sus principales limitaciones. Entre los modelos y las preparaciones empleados en la investigacion cardiovascular, se encuentran los basados en la utilizacion de celulas a…
Animal Models of Cardiovascular Disease
The use of animal models to study cardiovascular disease has made a substantial contribution to increasing our understanding of disease pathogenesis, has led to the development of diagnostic techniques, and has made it possible to verify the effectiveness of different preventative and therapeutic approaches, whether pharmacological or interventional. The main limitations stem from differences between human and experimentally induced pathology, in terms of both genetic regulatory mechanisms and factors that influence cardiovascular function. The experimental models and preparations used in cardiovascular research include those based on isolated cells or tissues or structures immersed in orga…