Dichte Klassen konvexer Polytope

Isotope shifts and nuclear-charge radii in singly ionizedCa40–48

The isotope shifts in the resonance lines 4${\mathit{s}}_{1/2}$\ensuremath{\rightarrow}4${\mathit{p}}_{1/2,3/2}$ in Ca ii have been measured for the isotopes $^{40\mathrm{\ensuremath{-}}48}\mathrm{Ca}$ by fast-ion-beam collinear laser spectroscopy. Atomic many-body perturbation theory was then used to calculate the electronic factor for the field shift, giving F=-285(3) MHz/${\mathrm{fm}}^{2}$. The estimate of the uncertainty in F is based on the agreement at the level of 1% for the 4s and 4p hyperfine structures obtained using the same wave functions which include core polarization and pair correlation to all orders. The theoretical value is in excellent agreement with the result F=-283(6)…

Predictive and prognostic value of magnesium serum level in FOLFIRI plus cetuximab or bevacizumab treated patients with stage IV colorectal cancer: results from the FIRE-3 (AIO KRK-0306) study.

Magnesium wasting is a frequent side effect of epidermal growth factor receptor (EGFR)-antibody treatment as magnesium-absorption mechanisms are dependent on EGFR signaling. EGFR-inhibition results in decreased renal reabsorption. There is evidence that hypomagnesemia during cetuximab treatment correlates with response. The prognostic role of hypomagnesemia during bevacizumab treatment has not been studied yet. Here, we evaluate the prognostic value of hypomagnesemia in patients with metastatic colorectal cancer treated with FOLFIRI plus cetuximab or bevacizumab as first-line therapy. A total of 391 of 752 patients of the firstline irinotecan study population had magnesium levels measured a…