Reduced VLDL clearance in ApoeNpc1 mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels

Niemann-Pick type C1 (NPC1) promotes the transport of LDL receptor (LDL-R)-derived cholesterol from late endosomes/lysosomes to other cellular compartments. NPC1-deficient cells showed impaired regulation of liver_X receptor (LXR) and sterol regulatory element-binding protein (SREBP) target genes. We observed that Apoe(-/-)Npc1(-/-) mice displayed a marked increase in total plasma cholesterol mainly due to increased VLDL, reflecting decreased clearance. Although nuclear SREBP-2 and Ldlr mRNA levels were increased in Apoe(-/-)Npc1(-/-) liver, LDL-R protein levels were decreased in association with marked induction of proprotein convertase subtilisin/kexin type 9 (Pcsk9) and inducible degrade…

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H∞ model reduction for discrete-time Markovian jump systems with deficient mode information

Published version of an article in the journal: Mathematical Problems in Engineering. Also available from the publisher at: http://dx.doi.org/10.1155/2013/537174 Open Access This paper investigates the problem of H∞ model reduction for a class of discrete-time Markovian jump linear systems (MJLSs) with deficient mode information, which simultaneously involves the exactly known, partially unknown, and uncertain transition probabilities. By fully utilizing the properties of the transition probability matrices, together with the convexification of uncertain domains, a new H∞ performance analysis criterion for the underlying MJLSs is first derived, and then two approaches, namely, the convex li…

Delay-Probability-Distribution-Dependent FIR Filtering Design with Envelope Constraints

Published version of an article in the journal: Mathematical Problems in Engineering. Also available from the publisher at: http://dx.doi.org/10.1155/2013/930927 Open Access This paper studies the problem of H∞ finite-impulse response (FIR) filtering design of time-delay system. The time-delay considered here is time-varying meanwhile with a certain stochastic characteristic, and the probability of delay distribution is assumed to be known. Furthermore, the requirement of pulse-shape is also considered in filter design. Employing the information about the size and probability distribution of delay, a delay-probability-distribution-dependent criterion is proposed for the filtering error syst…