0000000000190917

AUTHOR

J. M. Suárez-peñaranda

showing 3 related works from this author

The role of p21Waf1/CIP1 as a Cip/Kip type cell-cycle regulator in oral squamous cell carcinoma (Review)

2013

Oral Squamous Cell Carcinoma (OSCC) is biologically characterized by the accumulation of multiple genetic and molecular alterations that end up clinically characterized as a malignant neoplasm through a phenomenon known as multistep. The members of the Cip/Kip family, specifically p21 Waf 1/CIP1 , are responsible for cell cycle control, blocking the transition from phase G1 to phase S. We made a search of articles of peer-reviewed Journals in PubMed/ Medline, crossing the keywords. The goal of this paper is to determine the relationship between p21 Waf 1/ CIP1 expression and several clinical and pathological aspects of OSCC, their relationship with p53 and HPV, as well as genetic alteration…

Cyclin-Dependent Kinase Inhibitor p21Pathologymedicine.medical_specialtyRegulatorOdontologíaCarcinomamedicineBasal cellP21waf1 cip1General DentistryPathologicalMouth neoplasmOral Medicine and PathologyTransition (genetics)business.industryCell CycleReview-ArticleCell cyclemedicine.disease:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludstomatognathic diseasesOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASCancer researchCarcinoma Squamous CellSurgeryMouth Neoplasmsbusiness
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Osteonecrosis of the jaws in 194 patients who have undergone intravenous bisphosphonate therapy in Spain.

2014

Background: Osteonecrosis of the jaw (ONJ) is a destructive bone process in patients undergoing bisphosphonate therapy and it is modulated by local and systemic factors. The purpose of this article is to determine the prevalence of ONJ in patients who have undergone intravenous bisphosphonate therapy, and relate the risk factors described to establish a protocol to reduce the risk of developing ONJ. Material and Methods: We performed a retrospective study on 194 patients treated with IV bisphosponates, analyzing clinical and pathological variables. Results: The prevalence of ONJ was 12.9 %. The most remarkable complication was pain, which was reported by 80% of patients. The average age of …

AdultMalemedicine.medical_specialtyOdontologíaOral hygieneRisk FactorsmedicinePrevalenceHumansRisk factorGeneral DentistryPathologicalAgedRetrospective StudiesAged 80 and overBisphosphonate-associated osteonecrosis of the jawOral Medicine and PathologyBone Density Conservation AgentsDiphosphonatesbusiness.industryResearchRetrospective cohort studyMiddle Agedmedicine.disease:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludSurgeryOtorhinolaryngologySpainUNESCO::CIENCIAS MÉDICASEtiologySurgeryBisphosphonate-Associated Osteonecrosis of the JawFemaleOsteonecrosis of the jawComplicationbusinessMedicina oral, patologia oral y cirugia bucal
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Survival study of leukoplakia malignant transformation in a region of northern Spain

2017

Background Oral leukoplakia is the most common potentially malignant disorder (PMD) of the oral cavity. The objectives of this study are to determine the clinicopathologic features in a group of patients with oral leukoplakia of Northern Spain (Galicia), determining the factors associated to clinical risk and analyzing the malignant transformation of these patients. Material and Methods We included 85 patients. We recorded sex and age, habits like alcohol and tobacco, size, clinical appearance, site, number of lesions, and presence or absence of dysplasia. We assess the association between risk factors and transformation and developed a logistic regression analysis. Finally we used the Kapl…

AdultMalemedicine.medical_specialtyGastroenterologyMalignant transformationYoung Adult03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicineOral and maxillofacial pathologyCarcinomaHumansMedicineRisk factorGeneral DentistrySurvival rateSurvival analysisAgedLeukoplakiaAged 80 and overOral Medicine and Pathologybusiness.industryResearch030206 dentistryMiddle Aged:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseSurvival Ratestomatognathic diseasesCell Transformation NeoplasticOtorhinolaryngologySpainDysplasia030220 oncology & carcinogenesisUNESCO::CIENCIAS MÉDICASFemaleSurgeryLeukoplakia OralbusinessMedicina Oral Patología Oral y Cirugia Bucal
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