0000000000191555
AUTHOR
Blessing O. Umeokoli
A new depsidone derivative from mangrove sediment derived fungus
A new depsidone derivative botryorhodine I (1), along with eight known compounds (2-9) were obtained from solid rice cultures of the fungal strain, Lasiodiplodia theobromae M4.2-2 isolated from a mangrove sediment sample. The structures of the isolated compounds were elucidated on the basis of 1 D and 2 D NMR analysis as well as by HRESIMS. All compounds were evaluated for their cytotoxic potential against the mouse lymphoma cell line L5178Y as well as for their antibacterial activities against a panel of Gram-positive and Gram-negative bacterial strains. Compound 3 revealed potent cytotoxic activity with an IC50 of 7.3 µM whereas compound 7 showed selective anti-bacterial activity against …
A new depsidone derivative from mangrove sediment derived fungus Lasiodiplodia theobromae
A new depsidone derivative botryorhodine I (1), along with eight known compounds (2-9) were obtained from solid rice cultures of the fungal strain, Lasiodiplodia theobromae M4.2-2 isolated from a mangrove sediment sample. The structures of the isolated compounds were elucidated on the basis of 1 D and 2 D NMR analysis as well as by HRESIMS. All compounds were evaluated for their cytotoxic potential against the mouse lymphoma cell line L5178Y as well as for their antibacterial activities against a panel of Gram-positive and Gram-negative bacterial strains. Compound 3 revealed potent cytotoxic activity with an IC50 of 7.3 µM whereas compound 7 showed selective anti-bacterial activity against …
CCDC 1946592: Experimental Crystal Structure Determination
Related Article: Haiqian Yu, Simon-Patrick Höfert, Mariam Moussa, Christoph Janiak, Werner E.G. Müller, Blessing O. Umeokoli, Haofu Dai, Zhen Liu, Peter Proksch|2019|Tetrahedron Lett.|60|151325|doi:10.1016/j.tetlet.2019.151325
CCDC 1517632: Experimental Crystal Structure Determination
Related Article: Hao Wang, Blessing O. Umeokoli, Peter Eze, Christian Heering, Christoph Janiak, Werner E.G. Müller, Raha S. Orfali, Rudolf Hartmann, Haofu Dai, Wenhan Lin, Zhen Liu, Peter Proksch|2017|Tetrahedron Lett.|58|1702|doi:10.1016/j.tetlet.2017.03.052