6533b7d2fe1ef96bd125f841
RESEARCH PRODUCT
A new depsidone derivative from mangrove sediment derived fungus
Blessing O. UmeokoliWeaam EbrahimMona El-neketiWerner E. G. MüllerRainer KalscheuerWenhan LinZhen LiuPeter Prokschsubject
Magnetic Resonance SpectroscopyStereochemistryPlant ScienceFungus01 natural sciencesBiochemistryDepsidesAnalytical Chemistrychemistry.chemical_compoundLactonesMiceAscomycotaAnimalsIC50biology010405 organic chemistryChemistryDepsidoneOrganic ChemistryBiological activitybiology.organism_classification0104 chemical sciences010404 medicinal & biomolecular chemistryCell cultureWetlandsMangroveDerivative (chemistry)Lasiodiplodia theobromaedescription
A new depsidone derivative botryorhodine I (1), along with eight known compounds (2-9) were obtained from solid rice cultures of the fungal strain, Lasiodiplodia theobromae M4.2-2 isolated from a mangrove sediment sample. The structures of the isolated compounds were elucidated on the basis of 1 D and 2 D NMR analysis as well as by HRESIMS. All compounds were evaluated for their cytotoxic potential against the mouse lymphoma cell line L5178Y as well as for their antibacterial activities against a panel of Gram-positive and Gram-negative bacterial strains. Compound 3 revealed potent cytotoxic activity with an IC50 of 7.3 µM whereas compound 7 showed selective anti-bacterial activity against different S. aureus and E. faecium bacterial strains with MIC value of 25 µg/ml.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-08-21 | Natural product research |