Hydroxyurea induces centrosome amplification and slowing down of cell cycle in colo-cancer cells SW480

Effects of clearance on thick, single-lap bolted joints using through-the-thickness measuring techniques

Composite materials have increasingly become more common in ground transportation. As this occured thicker panels, as compared to composite panels used in aviation, become necessary in order to withstand high impact loads and day to day degradation. The effectiveness of these panels was often limited by the strength of the joint in which the panel was attached to the frame of the vehicle. Investigating methods of reducing strain concentrations within these joints would increase the effectiveness in using composite materials in ground transportation applications by increasing the load necessary for joint failure to occur. In this study, fiber optic strain gages were embedded in a composite p…

Cholesteatoma associated with Kabuki syndrome

Kabuki syndrome (KS), also identified as Kabuki make-up syndrome or Niikawa-Kuroki syndrome, is a multiple malformation/mental retardation syndrome that was described initially in Japan but is now known to occur in many other ethnic groups. The syndrome is characterized by varying degrees of mental retardation, postnatal growth retardation, distinct facial characteristics resembling the Kabuki actor's make-up, cleft or high-arched palate, brachydactyly, scoliosis, and persistence of finger pads. There is no definitive laboratory diagnostic test for KS, thus diagnosis is based on phenotypic presentation and the exclusion of other known syndromes. Familial cases have been reported and autosom…

Clinical and endoscopic presentation of primary gastric lymphoma: a multicentre study

1. Aliment Pharmacol Ther. 2006 Mar 15;23(6):721-6. Clinical and endoscopic presentation of primary gastric lymphoma: a multicentre study. Andriani A, Zullo A, Di Raimondo F, Patti C, Tedeschi L, Recine U, Caruso L, Bonanno G, Chiarenza A, Lizzani G, Miedico A, Romanelli A, Costa A, Linea C, Marrone C, Mirto S, Mistretta A, Montalbano L, Restivo G, Vinci M, Bibas M, Hassan C, Stella F, Cottone M, Morini S. Department of Haematology and Gastroenterology, 'San Giacomo' and 'Nuovo Regina Margherita' Hospitals, Rome, Italy. BACKGROUND: Although the stomach is the most frequent site of intestinal lymphomas, few data are available on both clinical endoscopic presentation of gastric lymphoma and p…

Effect of Cold Working and Ring Indentation on Fatigue Life of Aluminum Alloy Specimens

The article deals with the fatigue life of plates with hole made of aluminum alloy. Specifically, the combined effect of cold working expansion and ring indentation on improved fatigue life performance was investigated. Multiple fatigue tests were performed to determine the cycles to failure and the corresponding W¨ ohler diagram. Experimental results were compared with those of nontreated specimens. The conclusion was that cold working expansion and indentation create a delay on crack formation and fatigue failure.

Automated Stress Separation Along Stress Trajectories

A procedure for the separation of principal stresses in automated photoelasticity is presented. It is based on the integration of indefinite equations of equilibrium along stress trajectories, also known as Lame-Maxwell equations. A new algorithm for precise and reliable stress trajectory calculation, which is an essential feature of the procedure, has also been developed. Automated stress separation is carried out along stress trajectories starting from free boundaries. Experimental tests were performed on a disc in diametral compression and on a ring with internally applied pressure. Full-field principal stress values were obtained and results were compared with those from the theory of e…

Three-Dimensional Strain Analysis of Single-Lap Bolted Joints in Thick Composites Using Fibre-Optic Gauges and the Finite-Element Method

Bolted joints involving composite plates used to be almost entirely dedicated to aerospace applications. As the need for energy conservation has increased, the field of composite bolted joints has found new applications in ground armoured vehicles. Thick panels able to withstand large in-plane and impact loads are critical. The present investigation evaluates the interior strain field, through the thickness, of a composite plate connected to an aluminium panel with a single-lap bolted joint. The area of interest is the bearing plane region close to the hole because of the presence of stress concentrations that heavily modify the stress field. Experimental data for the bolted joint were rec…