Previsione degli arrivi delle navi ed ottimizzazione delle risorse umane in un terminal hub container

Previsione degli arrivi delle navi ed ottimizzazione delle risorse umane in un terminal hub container

Development of prediction models for container traffic

The purpose of the work described in this paper is to construct and implement prediction models for optimizing container handling in particular at Cagliari’s Terminal Container. Prediction models are based on heuristic algorithms such as neural networks and classification and regression trees and evolutionary algorithms such as Genetic Algorithms (GA) and Ant Colony Optimization (ACO). These models form part of a Web Oriented Decision Support System, for real time external data acquisition (GPS information, weather information, etc.), providing operators with the information processed in real time. The most commonly used parameter for assessing terminal performance is productivity, namely t…

ATNX2 is not a regulatory gene in Italian amyotrophic lateral sclerosis patients with C9ORF72 GGGGCC expansion

Abstract There are indications that both familial amyotrophic lateral sclerosis (ALS) and sporadic ALS phenotype and prognosis are partly regulated by genetic and environmental factors, supporting the theory that ALS is a multifactorial disease. The aim of this article was to assess the role of ATXN2 intermediate length repeats in a large series of Italian and Sardinian ALS patients and controls carrying a pathogenetic C9ORF72 GGGGCC hexanucleotide repeat. A total of 1972 ALS cases were identified through the database of the Italian ALS Genetic consortium, a collaborative effort including 18 ALS centers throughout Italy. The study population included: (1) 276 Italian and 57 Sardinian ALS ca…

Nuove strategie gestionali per la competitività di un terminal container di transhipment: sviluppo di strumenti di supporto alle decisioni per la pianificazione delle attività portuali

In a container terminal task assignment optimization may not be sufficient to ensure efficiency. By contrast, a systemic approach to terminal operations planning is required to ensure efficient coordination day by day of the all the operations in-volved. As far as management is concerned, a number of interacting factors need to be taken into account, ranging from prediction of ships’ arrivals to manpower and vehicles optimization strategies for the different work shifts. This paper describes three modules comprising a Decision Support System designed to assist port operations planners: - Ships’ arrivals forecasting module; - Optimal human resources allocation module; - Maintenance process e…

Linee Guida per la competitività dei porti container italiani nel sistema euro mediterraneo

CHCH10 mutations in an Italian cohort of familial and sporadic amyotrophic lateral sclerosis patients

Mutations in CHCHD10 have recently been described as a cause of frontotemporal dementia (FTD) comorbid with amyotrophic lateral sclerosis (ALS). The aim of this study was to assess the frequency and clinical characteristics of CHCHD10 mutations in Italian patients diagnosed with familial (n= 64) and apparently sporadic ALS (n= 224). Three apparently sporadic patients were found to carry c.100C>T (p.Pro34Ser) heterozygous variant in the exon 2 of CHCHD10. This mutation had been previously described in 2 unrelated French patients with FTD-ALS. However, our patients had a typical ALS, without evidence of FTD, cerebellar or extrapyramidal signs, or sensorineural deficits. We confirm that CHC…

Erythropoietin in amyotrophic lateral sclerosis: a multicentre, randomized, double blind, placebo controlled, phase III study.

Objective To assess the efficacy of recombinant human erythropoietin (rhEPO) in amyotrophic lateral sclerosis (ALS). Methods Patients with probable laboratory-supported, probable or definite ALS were enrolled by 25 Italian centres and randomly assigned (1:1) to receive intravenous rhEPO 40 000 IU or placebo fortnightly as add-on treatment to riluzole 100 mg daily for 12 months. The primary composite outcome was survival, tracheotomy or >23 h non-invasive ventilation (NIV). Secondary outcomes were ALSFRS-R, slow vital capacity (sVC) and quality of life (ALSAQ-40) decline. Tolerability was evaluated analysing adverse events (AEs) causing withdrawal. The randomisation sequence was computer-…