Root resorption caused by osteoma growth

introduction. Osteoma is a benign and asymptomatic neoplasm, consisting of well-differentiated mature bone. The solitary osteoma may be classified as: peripheral when arising from the periosteum, central when arising from the endosteum and extraskeletal when arising in soft tissue. The etiology of osteoma is still unclear. Some reported cas- es did have a clear history of trauma; however, this was not the case in the majority of cases. Whereas peripheral osteomas are fairly easy to diagnose, central osteomas pose a more challenging diagnostic problem and need to be differentiated from other similar lesions of the jaws, such as central ossifying fibroma, osteoblastoma, cementoblas- toma and …

Frequency of young patients with oral leukoplakia (OL) and oral lichen planus (OLP) in a population of Western Sicily

Osteonecrosis of the jaw after long-term oral bisphosphonates, followed by short-term denosumab treatment for osteoporosis: a case report

Bisphosphonates and denosumab are antiresoptive agents and are mainly used for management of metastatic bone cancer, osteoporosis and other diseases. Bisphosphonates (BP) can reduce skeletal related events (SRE) by 30–50%1; denosumab (D) has been found even more effective than BP2. BP and D have been both associated to osteonecrosis of the jaw (ONJ). We report a case of an osteoporotic woman (62 yrs), complaining maxillary intense pain after a recent tooth molar extraction, observed in July 2013 at our centre. She mentioned previous treatments with monthly ibandronate (Bonviva ® 150 mg) per os (from January 2003 to April 2010), risedronate (35 mg weekly, from May 2010 to May 2012) and two a…

Conservative treatment of a Riga-Fede disease: a case report

Riga-Fede disease (RFD) is clinically characterized by the presence of a traumatic ulceration on the ventral surface of the tongue in newborns and infants. It is frequentely associated with prematurely erupting primary teeth, but may also occur after the eruption of primary lower incisors in older infants with repetitive tongue thrusting habits and children with familiar dysautonomia (insensitivity to pain).

Use of porcine collagen matrix (Mucograft®) to promote the wound healing in the oral cavity

The aim of this study was to evaluate the use of a new collagen matrix (Mucograft®; Geistlich Pharma AG, Wol- husen, Switzerland) in the soft tissue reconstruction after excisional biopsy. The healing of soft tissues after bioptical excision tends to heal by secondary intention. To avoid this, the soft tissue grafts can be harvested from the palate, retromolar pad, or (if available) edentulous site. Disadvantages of harvesting the graft from the retromolar pad and edentulous site are minimal amount of tissue availability and thinner grafts are obtained. The use of collagen matrix is also reported in literature and could represent an optimal solution in the future. Mucograft® is a pure colla…

Close of a fistula between the nose and the oral cavity using a new collagen matrix

Osteonecrosis of the jaw after adjuvant endocrine therapy plus alendronate in a breast cancer patient

Background. Bisphosphonates-associated osteonecrosis of the jaws (BRONJ) is a serious complication, which has been defined by Bedogni et al. (1) as an adverse drug reaction consisting of progressive destruction and death of bone that affects the mandible and/or maxilla of patients exposed to the treatment with nitrogen-containing bisphosphonates (NBPs) in absence of a previous radiation treatment. Generally, IV NBPs have a strong association with BRONJ than oral NBPs as evidenced by the higher incidence of BRONJ (0-10%) in patients treated with IV drugs than in patients in oral therapy (<1%). Objectives. The aim of this study was to report a clinical case of BRONJ in an oncologic patient wh…

Influence of operator’s experience on the shaping and centering ability of WaveOne single-file system

Aim. The aim of this study was to assess the influence of operator experience on the centering ability of WaveOne reciprocating system on S-shape simulated root canals. Methods. Forty S-shaped canals in resin blocks were assigned in two groups (n=20 for each group). Groups 1 was shaped by an expert operator, postgraduate in endodontics with more of ten years experience, while a not expert operator, a student in the last year of study, with poor endodontic experience performed shaping in Groups 2. A first survey of canals has been made with K-file 10 to assess the working length (WL), after that the glide path was achieved with PathFile 1, 2, and 3 (Dentsply Maillefer) at the WL. Subsequentl…

Early onset ONJ in patient treated with denosumab and bevacizumab: case report

Follow-up of non-exposed ONJ related to bisphosphonate: a two-year study

Aim. Osteonecrosis of the jaw (ONJ) is a serious sideeffect of amine bisphosphonate (NBP) and/or other antiresorptive agents frequently used in the management of osteometabolic and cancer-related condition. The traditional ONJ definition exclude patients who present the non-exposed variant. However, according to recent data, staging and monitoring of ONJ should be closely linked to clinical and radiological manifestation regardless of the presence of bone exposed. The aim of this study was a descriptive analysis of a case series of patients with non-exposed ONJ (exclusively related to NBP) monitoring for two years. Methods. From 2012 to 2014, 16 patient [7 oncological (F/M=3/4; mean age=66,…

Methicillin-resistant staphylococcus aureus (MRSA) osteomyelitis of the mandible: a case report in pediatric patient

A review of 50 cases of ameloblastoma in Nigerians.

Objectives. The purpose of this study was the review of 50 ameloblastoma in Nigerian patients observed in the Hos- pital of Ibadan. Ameloblastoma represents nearly 1% of all neoplasm located in the oral cavity. In 80% of cases it could be found in the mandible: 70% of these involving the molar region or the ascending ramus, 20% the premolar region and 10% the anterior part. Ameloblastoma is considered a benign neoplasm with slow growing-pattern and lo- cally aggressive behaviour. Methods. We collected the clinicopathologic data of 50 ameloblastoma from the files of the Hospital of Ibadan. Results. The 50 ameloblastoma occurred in patients from 8 years to 64 years, 25 cases (50%) were in the…

Oral lesions as primary manifestations of acute agranulocytosis related to metamizole: a case report

L-PRF application in extraction sockets of bisphosphonate-treated patients: preliminary results

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe adverse event related to bisphosphonates (BPs) therapy; tooth extraction has been described as the main trigger. Autologous platelet concentrates, such Leukocyte-Platelet Rich Fibrin (L-PRF, Intraspin !) are designed to release platelet growth factors, improving the tissue healing in oral surgery. The aim of this study was to evaluate the efficacy and safety of our dental extraction protocol applied in BPs patients.

Mandibular torus as known OnJ risk factor: a case report of osteonecrosis of the jaw

RESTITUTIO AD INTEGRUM IN A CASE OF ONJ RELATED TO BEVACIZUMAB

Aim. Bevacizumab is a humanized recombinant monoclonal antibody that blocks vascular endothelial growth factor (VEGF). The activity of VEGF is the ability to promote the vascular endothelial cells proliferation inducing the formation of new blood vessels. Bevacizumab is used in the treatment of selected advanced colon, lung, renal and central nervous system tumours and plays a developing role in the management of breast and ovarian cancers. It is also injected intraocularly for treatment of macular degeneration. Recently, bevacizumab has been reported as responsible of drug-related osteonecrosis of the jaw (ONJ), showing a histological pattern similar to bisphosphonate-related ONJ. Moreover…