0000000000194784

AUTHOR

Gabriele Luppi

showing 3 related works from this author

An observational, multicenter, retrospective, Italian Sarcoma Group (ISG) study of trabectedin in patients with advanced soft tissue sarcoma (STS).

2018

e23502Background: Trabectedin (T) is approved for patients (pts) with STS after failure of anthracyclines (A) and ifosfamide (I), or pts unsuited to receive AI. ISG performed a retrospective study ...

OncologyCancer Researchmedicine.medical_specialtyIfosfamidebusiness.industrySoft tissue sarcomaRetrospective cohort studymacromolecular substancesmedicine.diseasecarbohydrates (lipids)stomatognathic diseasesOncologyInternal medicineotorhinolaryngologic diseasesbacteriaMedicineObservational studyIn patientSarcomabusinessTrabectedinmedicine.drugJournal of Clinical Oncology
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Activity and safety of temozolomide in advanced adrenocortical carcinoma patients

2019

Objective Temozolomide has shown a significant anti-proliferative activity on adrenocortical cancer (ACC) cells in vitro. Design On the basis of these results the drug was prescribed as second/third line in advanced metastatic ACC patients in four referral centers in Italy. Methods We retrospectively collected anagraphic, clinical and pathological data of patients with advanced ACC with disease progression to standard chemotherapy plus mitotane who were treated with temozolomide at the dose of 200 mg/m2/die given for 5 consecutive days every 28 days. The primary endpoint was the disease control rate, defined as objective response or disease stabilization after 3 months. Secondary endpoints…

AdultOncologymedicine.medical_specialtytemozolomide adrenocortical carcinomaDisease ResponseSettore MED/06 - Oncologia MedicaEndocrinology Diabetes and Metabolismmedicine.medical_treatment030209 endocrinology & metabolism03 medical and health sciences0302 clinical medicineEndocrinologyStable DiseaseInternal medicineAdrenocortical CarcinomaTemozolomideClinical endpointHumansMedicineAdrenocortical carcinomaMitotaneDNA Modification MethylasesAgedRetrospective StudiesChemotherapyTemozolomidebusiness.industryTumor Suppressor ProteinsRetrospective cohort studyGeneral MedicineMiddle Agedmedicine.diseaseDNA Repair EnzymesEndocrinology030220 oncology & carcinogenesisbusinessmedicine.drug
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Oral chemotherapy and patient perspective in solid tumors: a national survey by the Italian association of medical oncology.

2015

Aim To assess patient perception toward oral chemotherapy for solid tumors, the Italian Association of Medical Oncology performed a large multi-institutional national survey. Methods A 17-item anonymous questionnaire including 7 general and 10 investigational questions with free-text, single-choice, or multiple-choice answers was administered. Analysis of response distribution according to predefined factors was described by summary measures and conducted by χ2 test and other nonparametric tests. Results From January to June 2010, 581 patients completed the questionnaire; data of 404 patients constituted the final study sample. Three groups could be distinguished according to treatment: IV …

OncologyAdultMaleCancer Researchmedicine.medical_specialtyOral chemotherapyAdministration OralWork commitment03 medical and health sciences0302 clinical medicineInternal medicineNeoplasmsSurveys and QuestionnairesAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansImpact on family030212 general & internal medicineInfusions IntravenousOral therapyAgedbusiness.industryIntravenous chemotherapyGeneral MedicineMiddle AgedPatient perceptionsOncologyItaly030220 oncology & carcinogenesisQuality of LifeCombined therapyFemalebusinessTumori
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