0000000000195248

AUTHOR

Guido Ferlazzo

0000-0002-3874-8554

showing 4 related works from this author

Cognate HLA absence in trans diminishes human NK cell education

2016

NK cells are innate lymphocytes with protective functions against viral infections and tumor formation. Human NK cells carry inhibitory killer cell Ig-like receptors (KIRs), which recognize distinct HLAs. NK cells with KIRs for self-HLA molecules acquire superior cytotoxicity against HLA– tumor cells during education for improved missing-self recognition. Here, we reconstituted mice with human hematopoietic cells from donors with homozygous KIR ligands or with a mix of hematopoietic cells from these homozygous donors, allowing assessment of the resulting KIR repertoire and NK cell education. We found that co-reconstitution with 2 KIR ligand–mismatched compartments did not alter the frequenc…

0301 basic medicine10028 Institute of Medical VirologyEpstein-Barr Virus InfectionsHerpesvirus 4 HumanCellchemical and pharmacologic phenomena610 Medicine & healthMice SCIDHuman leukocyte antigen2700 General MedicineAdaptive ImmunityBiology10263 Institute of Experimental Immunology03 medical and health sciencesMice Inbred NOD10049 Institute of Pathology and Molecular PathologymedicineAnimalsHumansCytotoxicityReceptorHistocompatibility Antigens Class IHEK 293 cellsGeneral MedicineAcquired immune systemKiller Cells NaturalHaematopoiesisHEK293 Cells030104 developmental biologymedicine.anatomical_structureNatural-Killer-Cells Cord Blood Transplantation Cytomegalovirus-Infection Class-I Inhibitory receptors Pediatric Patients TumorsImmunologyK562 CellsResearch ArticleK562 cells
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Biological parameters in breast cancer.

1996

AdultAged 80 and overCA15-3Oncologymedicine.medical_specialtyPloidiesbusiness.industryGeneral NeuroscienceBreast NeoplasmsDNA NeoplasmMiddle AgedPrognosismedicine.diseaseGeneral Biochemistry Genetics and Molecular BiologyS PhaseBreast cancerHistory and Philosophy of ScienceEvaluation Studies as TopicInternal medicinemedicineHumansFemalebusinessAged
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Mucosal immunology and probiotics.

2013

The cross-talk between the mucosa-associated immune system and microbiota is critical in mucosal tissue homeostasis as well as in protection against infectious and inflammatory diseases occurring at mucosal sites. This recent evidence has paved the way to therapeutic approaches aimed at modulating the mucosa-associated immune system using probiotics. Different strains of probiotics possess the ability to finely regulate dendritic cell (DC) activation, polarizing the subsequent T cell activity toward Th1 (e.g. Lactobacillus (Lb) acidophilus), Th2 (Lb.reuteri and Bifidobacterium bifidum) or, as more recently demonstrated, Th17 responses induced by specific strains such as Lb.rhamnosus GG and …

Commensal bacteriaSettore MED/07 - Microbiologia E Microbiologia ClinicaAllergyPRRT- cell polarizationved/biology.organism_classification_rank.speciesAutoimmunityProbioticInflammatory bowel diseaseMALTTh1Th2Immunology and AllergyIECBifidobacteriumbiologyMicrobiotaImmune-mediated diseasefood and beveragesPAMPCrohn's diseasemedicine.anatomical_structureMucosal immunologyImmunotherapyTh17HumanPulmonary and Respiratory MedicineSettore MED/17 - Malattie InfettiveT cellImmunologyImmunopathologyDendritic CellMicrobiologyImmune systemBifidobacteriaImmunityTLRmedicineGALTAnimalsHumansImmunity MucosalLABLactobacilluInnate immune systemBifidobacterium bifidumUlcerative colitiMucous Membraneved/biologyAnimalProbioticsDendritic cellDendritic CellsInterleukinbiology.organism_classificationImmunity InnateLactobacillusMucosal immunologyLactobacilliImmune SystemImmunologyBifidobacteriumCurrent allergy and asthma reports
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Th17 skewing in the GALT of a Crohn disease patient upon Lactobacillus rhamnosus GG consumption.

2015

We wish to report on a recent observation we made and that might represent a useful hint for the employment of the so called probiotics in the management of some pathological immune reactions of the gut. By analyzing GALT-associated T cells upon consumption of L. rhamnosus-GG, we obtained some hints that probiotics might have locoregional immunological effects mainly when administered in patients with IBDs rather than in individuals with non-inflamed gut mucosa.

0301 basic medicineSettore MED/17 - Malattie InfettiveImmunologyBioinformaticsPeyer's PatcheProbioticInflammatory bowel diseaseTh17 Cell03 medical and health sciencesPeyer's Patches0302 clinical medicineLactobacillus rhamnosusCrohn DiseaseIntestinal mucosaImmunology and AllergyMedicineHumansConsumption (economics)Settore MED/04 - Patologia Generalebiologybusiness.industryCrohn diseaseLacticaseibacillus rhamnosusInflammatory bowel disease; Intestinal mucosa; Lactobacillus rhamnosus; Mucosal barrier; Probiotics; T cell polarizationProbioticsbiology.organism_classificationMucosal barrierT cell polarization030104 developmental biology030220 oncology & carcinogenesisImmunologyTh17 CellsLactobacillus rhamnosubusinessHumanImmunology letters
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