0000000000195379

AUTHOR

Zhen Wang

showing 10 related works from this author

Range of Normal Liver Stiffness and Factors Associated With Increased Stiffness Measurements in Apparently Healthy Individuals

2018

Background & Aims: Transient elastography (TE) is a noninvasive technique used to measure liver stiffness to estimate the severity of fibrosis. The range of liver stiffness measurements (LSMs) in healthy individuals is unclear. We performed a systematic review to determine the range of LSMs, examined by TE, in healthy individuals and individuals who are susceptible to fibrosis. Methods: We collected data from 16,082 individuals, in 26 cohorts, identified from systematic searches of Embase, Ovid MEDLINE, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews for studies of liver stiffness measurements. Studies analyzed included apparently healthy adul…

AdultMalemedicine.medical_specialtyCirrhosisAdolescent03 medical and health sciencesYoung AdultBMI0302 clinical medicineInternal medicineDiabetes mellitusNonalcoholic fatty liver diseasemedicineHumansObesityAgedAged 80 and overCirrhosiAnthropometryHepatologybusiness.industryGastroenterologyBMI; Cirrhosis; Fibroscan; Obesity; Hepatology; GastroenterologyMiddle Agedmedicine.diseaseElasticityHealthy VolunteersFibroscanLiver030220 oncology & carcinogenesisCohortElasticity Imaging Techniques030211 gastroenterology & hepatologyFemaleMetabolic syndromeTransient elastographybusinessBody mass indexDyslipidemiaClinical Gastroenterology and Hepatology
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Treatments used for obsessive-compulsive disorder-An international perspective.

2018

Objective The objective of this study was to characterise international trends in the use of psychotropic medication, psychological therapies, and novel therapies used to treat obsessive–compulsive disorder (OCD). Methods Researchers in the field of OCD were invited to contribute summary statistics on the characteristics of their samples. Consistency of summary statistics across countries was evaluated. Results The study surveyed 19 expert centres from 15 countries (Argentina, Australia, Brazil, China, Germany, Greece, India, Italy, Japan, Mexico, Portugal, South Africa, Spain, the United Kingdom, and the United States) providing a total sample of 7,340 participants. Fluoxetine (n = 972; 13…

MaleObsessive-Compulsive DisorderInternationalitymedicine.medical_treatmentDeep Brain StimulationSocial SciencesFluvoxamineBENZODIAZEPINASpharmacotherapyBenzodiazepines0302 clinical medicinePharmacology (medical)TERAPIA PSICOANALITICAPSICOFARMACOLOGIAantipsychotics; benzodiazepines; cross-cultural study; obsessive-compulsive disorder; pharmacotherapy; selective serotonin reuptake inhibitorsMiddle Aged3. Good healthExposure and response preventionantipsychotics; benzodiazepines; cross-cultural study; obsessive–compulsive disorder; pharmacotherapy; selective serotonin reuptake inhibitorsNeurologyPsychiatry and Mental HealthSerotonin Uptake Inhibitorscross-cultural studyAripiprazoleFemalebenzodiazepineSelective Serotonin Reuptake Inhibitorsmedicine.drugPsychosurgeryAntipsychotic AgentsAdultmedicine.medical_specialty:Ciências da Saúde [Ciências Médicas]Ciências Médicas::Ciências da SaúdeSerotonin reuptake inhibitor03 medical and health sciencesANTIPSICOTICOSobsessive–compulsive disorderselective serotonin reuptake inhibitorsmedicinePSICOTROPICOSHumansAntipsychoticPsychiatryFARMACOTERAPIAFluoxetineRisperidoneantipsychotics; benzodiazepines; cross-cultural study; obsessive–compulsive disorder; pharmacotherapy; selective serotonin reuptake inhibitors; Neurology; Neurology (clinical); Psychiatry and Mental Health; Pharmacology (medical)Science & Technologyselective serotonin reuptake inhibitorbusiness.industryTRASTORNO OBSESIVO COMPULSIVO030227 psychiatryantipsychoticPsychosurgeryantipsychoticsNeurology (clinical)business030217 neurology & neurosurgerySEROTONINAHuman psychopharmacology
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Search for new phenomena in dijet events using 37  fb−1 of pp collision data collected at s=13  TeV with the ATLAS detector

2017

Dijet events are studied in the proton-proton collision dataset recorded at root s = 13 TeV with the ATLAS detector at the Large Hadron Collider in 2015 and 2016, corresponding to integrated lumino ...

PhysicsParticle physicsLarge Hadron ColliderPhysics::Instrumentation and Detectors010308 nuclear & particles physicsAtlas detectorHigh Energy Physics::PhenomenologyCollision01 natural sciencesNuclear physicsAngular distributionmedicine.anatomical_structureAtlas (anatomy)0103 physical sciencesmedicinePhysics::Accelerator PhysicsHigh Energy Physics::ExperimentNuclear Experiment010306 general physicsPhysical Review D
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RNF2 Mediates Hepatic Stellate Cells Activation by Regulating ERK/p38 Signaling Pathway in LX-2 Cells

2021

The therapeutic approach of liver fibrosis is still an unsolved clinical problem worldwide. Notably, the accumulation of extracellular matrix (ECM) in the liver is mediated by the production of cytokines and growth factors, such as transforming growth factor-β1 (TGF-β1) in hepatic stellate cells (HSCs). Ring finger protein 2 (RNF2) was identified as the catalytic subunit of polycomb repressive complex 1 (PRC1), mediating the monoubiquitination of histone H2A. In recent years, a growing amount of evidence suggests that RNF2 may play an important role in multiple pathological processes involved in cancer. Here, we explored the role of RNF2 in liver fibrogenesis and its potential mechanisms. T…

MAPK/ERK pathwayGene knockdownChemistryCell growthp38 mitogen-activated protein kinasesapoptosisRNF2Cell BiologyCell biologyExtracellular matrixCell and Developmental BiologyLX-2 cellslcsh:Biology (General)Downregulation and upregulationinflammationMAPK signaling pathwayHepatic stellate cellSignal transductionlcsh:QH301-705.5Original Researchliver fibrosisDevelopmental BiologyFrontiers in Cell and Developmental Biology
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Observation of Two NewN*Resonances in the Decayψ(3686)→pp¯π0

2013

Based on 106 x 10(6)psi(3686) events collected with the BESIII detector at the BEPCII facility, a partial wave analysis of psi(3686) -> p (p) over bar pi(0) is performed. The branching fraction of this channel has been determined to be B psi(3686) -> p (p) over bar pi(0) = (1.65 +/- 0.03 +/- 0.15) x 10(-4). In this decay, 7 N* intermediate resonances are observed. Among these, two new resonances, N(2300) and N(2570) are significant, one 1/2(+) resonance with a mass of 2300(-30-0)(+40+109) MeV/c(2) and width of 340(-30-58)(+30+110) MeV/c(2), and one 5/2(-) resonance with a mass of 2570(-10-10)(+19+34) MeV/c(2) and width of 250(-24-21)(+14+69) MeV/c(.)(2) For the remaining 5 N* intermediate r…

BaryonNuclear physicsPhysicsBranching fractionElectron–positron annihilationPartial wave analysisAnalytical chemistryGeneral Physics and AstronomyResonanceBar (unit)Physical Review Letters
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Partial wave analysis ofJ/ψ→γηη

2013

Based on a sample of 2.25 x 10(8) J/psi events collected with the BESIII detector at BEPCII, a full partial wave analysis on J/psi -> gamma eta eta was performed using the relativistic covariant tensor amplitude method. The results show that the dominant 0(++) and 2(++) components are from the f(0)(1710), f(0)(2100), f(0)(1500), f(2)'(1525), f(2)(1810) and f(2)(2340). The resonance parameters and branching fractions are also presented.

PhysicsNuclear and High Energy PhysicsAmplitudeClassical mechanicsMesonBranching fractionElectron–positron annihilationPartial wave analysisAnalytical chemistryddc:530High Energy Physics::ExperimentPhysical Review D
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The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges.

2019

The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily. Recent studies have suggested that the TRPA1 channel plays an essential role in the development and progression of several cardiovascular conditions, such as atherosclerosis, heart failure, myocardial ischemia–reperfusion injury, myocardial fibrosis, arrhythmia, vasodilation, and hypertension. Activation of the TRPA1 channel has a protective effect against the development of atherosclerosis. Furthermore, TRPA1 channel activation elicits peripheral vasodilation and induces a biphasic bl…

0301 basic medicinemedicine.medical_specialtyhypertensionheart failureVasodilationReviewTRPA1 Channelarrhythmia03 medical and health sciencesTransient receptor potential channel0302 clinical medicineInternal medicinemedicineTRPA1 channelAnkyrinPharmacology (medical)vasodilationchemistry.chemical_classificationPharmacologybusiness.industrylcsh:RM1-950food and beveragesmedicine.diseaseBlockademyocardial ischemia–reperfusion injurylcsh:Therapeutics. Pharmacology030104 developmental biologyBlood pressurechemistry030220 oncology & carcinogenesisHeart failureCardiologyMyocardial fibrosismyocardial fibrosisatherosclerosisbusinesspsychological phenomena and processesFrontiers in pharmacology
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Autophagy

2012

Klionsky, Daniel J. et al.

autophagy assays[SDV]Life Sciences [q-bio]AutolysosomeAutophagosome maturationautophagosomeBioinformaticsstressChaperone-mediated autophagyModelsLC3MESH: Animalsguidelinesautolysosome autophagosome flux LC3 lysosome phagophore stress vacuoleSettore BIO/06 - Anatomia Comparata E CitologiaComputingMilieux_MISCELLANEOUSSettore BIO/17Autophagy databaseautolysosome3. Good healthddc:540lysosomeEnergy and redox metabolism Mitochondrial medicine [NCMLS 4]methods [Biological Assay]Biological AssaySettore BIO/17 - ISTOLOGIANeuroniMAP1LC3BHumanautophagygenetics [Autophagy]AutofagiaMESH: Autophagy*/genetics[SDV.BC]Life Sciences [q-bio]/Cellular BiologyAutofagia; Neuroni; istologiaBiologyModels BiologicalLC3; autolysosome; autophagosome; flux; lysosome; phagophore; stress; vacuoleddc:570AutophagyAnimalsHumansAutophagy-Related Protein 7[SDV.BC] Life Sciences [q-bio]/Cellular BiologyBiological Assay/methodsMolecular BiologyBiologyAutophagy; guidelines; autophagy assaysistologiaphagophoreMESH: HumansAnimals; Biological Assay; Humans; Models Biological; AutophagyvacuoleAnimal[ SDV.BC ] Life Sciences [q-bio]/Cellular BiologyMESH: Models BiologicalPathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1]Cell BiologyBiologicalAutophagy/geneticsfluxAutophagosome membraneAutophagy Protein 5Human medicineMESH: Biological Assay/methods*Neuroscienceautolysosome; autophagosome; flux; LC3; lysosome; phagophore; stress; vacuoleAutophagy
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Precise Measurement of the e+e−→π+π−J/ψ Cross Section at Center-of-Mass Energies from 3.77 to 4.60 GeV

2017

The cross section for the process e(+)e(-)-> pi(+) pi(-) J/psi is measured precisely at center-of-mass energies from 3.77 to 4.60 GeV using 9 fb(-1) of data collected with the BESIII detector operating at the BEPCII storage ring. Two resonant structures are observed in a fit to the cross section. The first resonance has a mass of (222.0 +/- 3.1 +/- 1.4) MeV/ c(2) and a width of (44.1 +/- 4.3 +/- 2.0)MeV, while the second one has a mass of (4320.0 +/- 10.4 +/- 7.0)MeV/c(2) and a width of (101.4(- 19.7)(+25.3) +/- 10.2) MeV, where the first errors are statistical and second ones are systematic. The first resonance agrees with the Y(4260) resonance reported by previous experiments. The precisi…

Nuclear physicsPhysicsCross section (physics)010308 nuclear & particles physics0103 physical sciencesGeneral Physics and AstronomySigmaCenter of mass010306 general physics01 natural sciencesResonance (particle physics)Belle experimentStorage ringPhysical Review Letters
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Precise Measurement of the e+e− → π+π−J/ψ Cross Section at Center-of-Mass Energies from 3.77 to 4.60 GeV

2020

The cross section for the process e(+)e(-)-> pi(+) pi(-) J/psi is measured precisely at center-of-mass energies from 3.77 to 4.60 GeV using 9 fb(-1) of data collected with the BESIII detector operating at the BEPCII storage ring. Two resonant structures are observed in a fit to the cross section. The first resonance has a mass of (222.0 +/- 3.1 +/- 1.4) MeV/ c(2) and a width of (44.1 +/- 4.3 +/- 2.0)MeV, while the second one has a mass of (4320.0 +/- 10.4 +/- 7.0)MeV/c(2) and a width of (101.4(- 19.7)(+25.3) +/- 10.2) MeV, where the first errors are statistical and second ones are systematic. The first resonance agrees with the Y(4260) resonance reported by previous experiments. The precisi…

Nuclear physicsPhysicsCross section (physics)SigmaCenter of massResonance (particle physics)Belle experimentStorage ring30 Years of BES Physics
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